John F Valliant - McMaster Experts

Affiliations

McMaster University,
Faculty of Science, McMaster University
Member, Biointerfaces Institute, Faculty of Science
Professor, Chemistry & Chemical Biology, Faculty of Science
Associate Member, Interdisciplinary Science, Faculty of Science
Canada Research Chair in Medical Isotopes and Molecular Imaging Probes, McMaster University,

Scholarly Activity in McMaster Experts

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chapters
- The Radiopharmaceutical Chemistry of Technetium-99m. 311-333. 2019
- ₄₃ Tc Technetium in Medicine. 333-358. 2005
conferences
- 70 Quantifying Tumour Dose Using Individualized Dosimetry Methodology in 177LU Dotatate Therapy. Radiotherapy and Oncology. S32-S32. 2019
- Preliminary Results of a Two Stage Phase II Study of 18F-DCFPyL PET-MR for Enabling Oligometastases Ablative Therapy in Subclinical Prostate Cancer. International Journal of Radiation Oncology Biology Physics. E276-E276. 2019
- Quantifying Renal And Tumor Doses with Individualized Dosimetry In 177Lu DOTATATE Therapy – What Difference Does It Make?. International Journal of Radiation Oncology Biology Physics. S205-S205. 2019
- A phase I study of [²²⁵Ac]-FPI-1434 radioimmunotherapy in patients with IGF-1R expressing solid tumors.. Journal of Clinical Oncology. TPS3152-TPS3152. 2019
- Comparison study of TCO-functionalized vector systems for in vivo click chemistry using [In-111]In-DOTA-Tetrazine. European Journal of Nuclear Medicine and Molecular Imaging. S242-S242. 2017
- Encapsulation of Radiolabeled Tetrazines in Pluronic F127 Nanoparticles for Pre-targeted SPECT Imaging and Radiotherapy using Bioorthogonal Chemistry. Journal of Labelled Compounds and Radiopharmaceuticals. S103-S103. 2017
- Imidazole-Fused Phenanthroline-Dyes for the Preparation of Multimodal Nuclear and Optical Imaging Probes. Journal of Labelled Compounds and Radiopharmaceuticals. S605-S605. 2017
- Preparation and in vivo testing of Tc-99m(I)-tetrazines for pretargeted imaging. Journal of Labelled Compounds and Radiopharmaceuticals. S92-S92. 2017
- Pretargeted PET Imaging of Bone Using a Trans-cyclooctene-Labeled Bisphosphonate. Journal of Labelled Compounds and Radiopharmaceuticals. S180-S180. 2017
- Radiolabeled nanoscale gas vesicles using bioorthogonal chemistry for multimodal SPECT and ultrasound imaging. Journal of Labelled Compounds and Radiopharmaceuticals. S281-S281. 2017
- Silicon/Fluorine-18/PSMA: A winning team for PET imaging of prostate cancer. Journal of Labelled Compounds and Radiopharmaceuticals. S353-S353. 2017
- Synthesis of radiolabelled antibody recruiting small molecules (radio-ARMs) for combined radio and immune therapy using bioorthogonal chemistry. Journal of Labelled Compounds and Radiopharmaceuticals. S20-S20. 2017
- Targeting prostate-specific membrane antigen (PSMA) with F-18-labeled compounds: The influence of prosthetic groups on tumor uptake. Journal of Labelled Compounds and Radiopharmaceuticals. S81-S81. 2017
- Direct Production of 99mTc via 100Mo(p,2n) on Small Medical Cyclotrons. Physics Procedia. 383-395. 2015
- Imidazole stabilized [2+1] Re(I)/99mTc(I) complexes as isostructural nuclear and optical probes. Nuclear Medicine and Biology. 616-616. 2014
- Synthesis and evaluation of single amino acid chelate (SAAC) tetrazine derivatives for bioorthogonal conjugation with Re/99mTc. Nuclear Medicine and Biology. 614-615. 2014
- The preparation and preclinical evaluation of 99mTc-labeled microbubbles for bimodal ultrasound and SPECT imaging. Nuclear Medicine and Biology. 628-628. 2014
- A new transfer system for solid targets. AIP Conference Proceedings. 146-151. 2012
- A New Generation of M(I) Chelates for Correlating in vitro and in vivo Imaging. Journal of Labelled Compounds and Radiopharmaceuticals. S20-S20. 2011
- A New Strategy for Labeling Unreactive Peptides and Proteins with N-Succinimidyl 4-[F-18]Fluorobenzoate ([F-18]SFB) using water-in-oil microemulsions. Journal of Labelled Compounds and Radiopharmaceuticals. S491-S491. 2011
- Assessing the potential of using the Mo-100(p,2n)Tc-99m transformation as a means of producing Curie-quantities of Tc-99m on existing cyclotron infrastructure. Journal of Labelled Compounds and Radiopharmaceuticals. S247-S247. 2011
- Emulsion reactors; A new platform for the synthesis of metal-based molecularimaging agents. Journal of Labelled Compounds and Radiopharmaceuticals. S12-S12. 2011
- Preparation and Evaluation of Halogenated and Metallated Cathepsin B Inhibitors as Molecular Imaging Agents. Journal of Labelled Compounds and Radiopharmaceuticals. S197-S197. 2011
- Triazole Appending Agent (TAAG): A new hydrophilic iodine-containing prosthetic group for the preparation of targeted radiopharmaceuticals. Journal of Labelled Compounds and Radiopharmaceuticals. S570-S570. 2011
- A new platform for the preparation of 99mTc receptor targeted probes using droplet microreactors. Nuclear Medicine and Biology. 698-698. 2010
- Metallocarborane-based bisphosphonates for tumour imaging and therapy. Nuclear Medicine and Biology. 681-682. 2010
- Technetium-labelled cathepsin B inhibitors as molecular imaging agents. Nuclear Medicine and Biology. 681-681. 2010
- The preparation of a Tc-Labeled analogue of phenylalanine for labeling peptides. Nuclear Medicine and Biology. 679-679. 2010
- bis-Benzimidazole single-amino acid chelates. Nuclear Medicine and Biology. 682-682. 2010
- A NEW STRATEGY FOR THE PREPARATION AND PURIFICATION OF TC-BASED RADIOPHARMACEUTICALS. Journal of Labelled Compounds and Radiopharmaceuticals. S459-S459. 2009
- DISCOVERY AND EVALUATION OF A POTENTIAL MOLECULAR IMAGING AGENT FOR CATHEPSIN B. Journal of Labelled Compounds and Radiopharmaceuticals. S134-S134. 2009
- SYNTHESIS OF 18F-RADIOTRACERS IN HIGH SPECIFIC ACTIVITY USING THE FLUOROUS APPROACH. Journal of Labelled Compounds and Radiopharmaceuticals. S177-S177. 2009
- SYNTHESIS, RADIOLABELLING AND BIOLOGICAL EVALUATION OF TARGETED METALLACARBORANE (M=99MTc) DERIVATIVES FOR IMAGING NEURORECEPTORS. Journal of Labelled Compounds and Radiopharmaceuticals. S21-S21. 2009
- THE PREPARATION AND IN VITRO EVALUATION OF CARBORANE SELECTIVE ESTROGEN RECEPTOR MODULATORS. Journal of Labelled Compounds and Radiopharmaceuticals. S343-S343. 2009
- INOR 381-New strategies for probe production, development and discovery. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008
- A NEW STRATEGY FOR LABELING BIOMOLECULES THAT CONTAIN DISULFIDE BONDS WITH RHENIUM AND TECHNETIUM. Journal of Labelled Compounds and Radiopharmaceuticals. S50-S50. 2005
- ACHIEVEING HIGH (APPARENT) SPECIFIC ACTIVITY FORMULATIONS USING FLUOROUS-PHASE CHEMISTRY. Journal of Labelled Compounds and Radiopharmaceuticals. S18-S18. 2005
- CARBORANE DERIVATIVES FOR TARGETING Tc-99m TO NEURORECEPTORS. Journal of Labelled Compounds and Radiopharmaceuticals. S45-S45. 2005
- ISO-STRUCTURAL FLUORESCENT AND Tc-99m PROBES FOR LABELING BIOMOLECULES. Journal of Labelled Compounds and Radiopharmaceuticals. S44-S44. 2005
- eta(5)-TYPE ORGANOMETALLIC COMPOUNDS AND THE PREPARATION OF Tc RADIOTRACERS. Journal of Labelled Compounds and Radiopharmaceuticals. S244-S244. 2005
- Preparation of synthons for carborane containing macromolecules. Macromolecular Symposia. 201-211. 2003
- A flexible and automated solid phase synthesis strategy for the preparation of novel radiopharmaceuticals.. Journal of Nuclear Medicine. 307P-307P. 2003
- Bifunctional single amino acid chelates (SAAC) as synthons for the solid phase synthesis of Tc(I) and Re(I) radiopharmaceuticals.. Journal of Nuclear Medicine. 48P-48P. 2003
- Single amino acid based bifunctional chelates for labeling of biomolecules with the {M(CO)(3)}(+) core and a novel {M(X)(3)} core (M = Tc/Re).. Journal of Nuclear Medicine. 50P-51P. 2003
- The synthesis and X-ray crystallographic structure determination of 3-isocyano-1,2-dicarba-closo-dodecaborane-Re(I) complexes. Journal of Organometallic Chemistry. 25-30. 2003
journal articles
- Photoacoustic imaging of a cyanine dye targeting bacterial infection. Scientific Reports. 14:18322. 2024
- 89Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs. EJNMMI Research. 14:29. 2024
- Synthesis and Evaluation of Fluorous-Tagged and Polystyrene-Supported Precursors for Fluoro-benziodoxole. Synthesis. 55:2730-2736. 2023
- Tetrazine-Derived Near-Infrared Dye for Targeted Photoacoustic Imaging of Bone. Journal of Medicinal Chemistry. 66:6025-6036. 2023
- Abstract LB313: EGFRvIII-targeted alpha therapy shows significant therapeutic efficacy as both a single-agent and in combination with standard of care against preclinical GBM models. Cancer Research. 83:lb313-lb313. 2023
- Abstract 5041: TEM-1 targeted alpha therapeutic [Ac-225]-FPI-1848 induces regression in pre-clinical sarcoma xenograft models. Cancer Research. 83:5041-5041. 2023
- Abstract 5045: NTSR1-targeted alpha therapeutic [Ac-225]-FPI-2059 induces growth inhibition in a preclinical colorectal tumor model. Cancer Research. 83:5045-5045. 2023
- A multimodal SPECT: photoacoustic imaging agent for bacterial infection. Nuclear Medicine and Biology. 114-115:S62-S63. 2022
- A pretargeting approach to PET imaging with antibodies. Nuclear Medicine and Biology. 114-115:S59-S60. 2022
- Preclinical development of CD133 targeted immunoPET probes. Nuclear Medicine and Biology. 114-115:S19-S20. 2022
- Pretargeted PET of Osteodestructive Lesions in Dogs. Molecular Pharmaceutics. 19:3153-3162. 2022
- Transition metal-free fluorocyclization of unsaturated N-methoxyamides gives cyclic N-methoxyimidates. Tetrahedron. 123:132982-132982. 2022
- A bioorthogonal methylene blue derived probe for targeted photoacoustic imaging. European Journal of Medicinal Chemistry Reports. 4:100021-100021. 2022
- Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [18F]DCFPyL-PET: comparison to [18F]fluorocholine-PET. EJNMMI Research. 11:2. 2021
- Synthesis and Preclinical Evaluation of [¹⁸F]SiFA-PSMA Inhibitors in a Prostate Cancer Model. Journal of Medicinal Chemistry. 64:15671-15689. 2021
- Prospective, Single-Arm Trial Evaluating Changes in Uptake Patterns on Prostate-Specific Membrane Antigen–Targeted ¹⁸F-DCFPyL PET/CT in Patients with Castration-Resistant Prostate Cancer Starting Abiraterone or Enzalutamide. Journal of Nuclear Medicine. 62:1430-1437. 2021
- Curative-intent Metastasis-directed Therapies for Molecularly-defined Oligorecurrent Prostate Cancer: A Prospective Phase II Trial Testing the Oligometastasis Hypothesis. European Urology. 80:374-382. 2021
- A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules. Molecular Pharmaceutics. 18:2647-2656. 2021
- Abstract LB130: Combination of IGF-1R targeted alpha therapy with Olaparib results in synergistic efficacy against colorectal and lung cancer xenografts. Cancer Research. 81:LB130-LB130. 2021
- Abstract LB155: Combination of IGF-1R targeted alpha therapy with checkpoint inhibitors results in synergistic efficacy in a syngeneic colorectal tumor model. Cancer Research. 81:LB155-LB155. 2021
- Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer. International Journal of Molecular Sciences. 22:4843-4843. 2021
- ^99mTc-Functionalized Single-Walled Carbon Nanotubes for Bone Targeting. ACS Applied Nano Materials. 3:11819-11824. 2020
- Imidazole fused phenanthroline (PIP) ligands for the preparation of multimodal Re(i) and ^99mTc(i) probes. Dalton Transactions. 49:14826-14836. 2020
- Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents. Molecular Pharmaceutics. 17:3369-3377. 2020
- 4: Caro Acura 2016 Primary Analysis of a Phase II Study of Metastasis-Directed Ablative Therapy to Psma (18F-DCFPYL) Pet-Mr/ Ct Defined Oligorecurrent Prostate Cancer. Radiotherapy and Oncology. 150:S6-S6. 2020
- Primary analysis of a phase II study of metastasis-directed ablative therapy to PSMA (¹⁸F-DCFPyL) PET-MR/CT defined oligorecurrent prostate cancer.. Journal of Clinical Oncology. 38:5553-5553. 2020
- [¹⁸F]DCFPyL PET-MRI/CT for unveiling a molecularly defined oligorecurrent prostate cancer state amenable for curative-intent ablative therapy: study protocol for a phase II trial. BMJ Open. 10:e035959-e035959. 2020
- Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging. Molecules. 25:463-463. 2020
- A Versatile Immune-Stimulatory Actinium-225 Complex for Combination Radiotherapy and Antibody Recruiting Therapy. Journal of Medical Imaging and Radiation Sciences. 50:S103-S103. 2019
- Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging. EJNMMI Research. 9:49. 2019
- IGF-1R Targeted Alpha Therapeutic FPI-1434 causes DNA Double-stranded Breaks and Induces Regression in Preclinical Models of Human Cancer. Journal of Medical Imaging and Radiation Sciences. 50:S86-S86. 2019
- A new approach for labelling near-infrared dyes with 99mTc for combined SPECT and photoacoustic imaging of calcium accretion. Nuclear Medicine and Biology. 72-73:S2-S2. 2019
- A platform for delivery of small molecules using trans-cyclooctene-functionalized pluronic F127 micelles. Nuclear Medicine and Biology. 72-73:S64-S64. 2019
- A versatile immune-stimulatory radiometal complex for combination radiotherapy and immunotherapy. Nuclear Medicine and Biology. 72-73:S12-S13. 2019
- Cyclotron-based production of Tc-99m and other metals. Nuclear Medicine and Biology. 72-73:S6-S7. 2019
- Drug formulation and its impact on the distribution of [99mTc] Tc-tetrazines for pretargeting applications via inverse-electron demand Diels-Alder chemistry. Nuclear Medicine and Biology. 72-73:S26-S26. 2019
- Moving towards clinical translation of bioorthogonal chemistry: preparation and testing of a 99mTc instant kit for imaging and treating bone injury using inverse-electron demand Diels-Alder (IEDDA) chemistry. Nuclear Medicine and Biology. 72-73:S30-S30. 2019
- Targeted radiopharmaceuticals for nuclear imaging and radiotherapy of CD133-positive tumors. Nuclear Medicine and Biology. 72-73:S49-S49. 2019
- Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging. Bioorganic and Medicinal Chemistry Letters. 29:986-990. 2019
- A Versatile Immune-Stimulatory Actinium-225 Complex for Combination Radiotherapy and Antibody Recruiting Therapy. Journal of Medical Imaging and Radiation Sciences. 50:S32-S32. 2019
- IGF-1R Targeted Alpha Therapeutic FPI-1434 causes DNA Double-stranded Breaks and Induces Regression in Preclinical Models of Human Cancer. Journal of Medical Imaging and Radiation Sciences. 50:S17-S18. 2019
- Preliminary results of a two stage phase II study of ¹⁸F-DCFPyL PET-MR for enabling oligometastases ablative therapy in subclinical prostate cancer.. Journal of Clinical Oncology. 37:250-250. 2019
- [18F]-DCFPyL Positron Emission Tomography/Magnetic Resonance Imaging for Localization of Dominant Intraprostatic Foci: First Experience. European Urology Focus. 4:702-706. 2018
- In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures. Molecular Imaging and Biology. 20:230-239. 2018
- Flare on Serial Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL PET/CT Examinations in Castration-Resistant Prostate Cancer: First Observations.. Clinical Nuclear Medicine. 43:213-216. 2018
- The next generation of radioimmunotherapy: Targeted alpha therapy (TAT). Annals of Oncology. 29:iii6-iii6. 2018
- Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: the Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile. Molecular Imaging and Biology. 19:923-932. 2017
- 18 F-Labeled perfluorocarbon droplets for positron emission tomography imaging. Nuclear Medicine and Biology. 54:27-33. 2017
- Preparation of tetrazine-containing [2 + 1] complexes of ^99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry. Dalton Transactions. 46:14691-14699. 2017
- 67 Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes. Nuclear Medicine and Biology. 52:32-41. 2017
- Technetium(I) Complexes of Bathophenanthrolinedisulfonic Acid. Inorganic Chemistry. 56:2958-2965. 2017
- Preparation and Evaluation of <sup>99m</sup>Tc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry. Journal of Visualized Experiments. 2017. 2017
- Preparation of an ¹⁸F‐Labeled Hydrocyanine Dye as a Multimodal Probe for Reactive Oxygen Species. Chemistry - A European Journal. 23:254-258. 2017
- Correction: A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS ONE. 12:e0171909-e0171909. 2017
- Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry. PLoS ONE. 12:e0176958-e0176958. 2017
- Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models. EJNMMI Research. 6:40. 2016
- A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using ^99mTc- and ¹⁷⁷Lu-Labeled Tetrazines. Journal of Medicinal Chemistry. 59:9381-9389. 2016
- Synthesis of Polyester Dendritic Scaffolds for Biomedical Applications. Macromolecular Bioscience. 16:1475-1484. 2016
- A Bridge Not Too Far: Linking Disciplines Through Molecular Imaging Probes. Journal of Nuclear Medicine Technology. 44:173-183. 2016
- Synthesis, radiolabelling, and biodistribution studies of triazole derivatives for targeting melanoma. Canadian Journal of Chemistry. 94:773-780. 2016
- Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy. Journal of Medicinal Chemistry. 59:2660-2673. 2016
- Design and synthesis of [ 125 I]Pyricoxib: A novel 125 I-labeled cyclooxygenase-2 (COX-2) inhibitors. Bioorganic and Medicinal Chemistry Letters. 26:1516-1520. 2016
- ¹²⁵I-Tetrazines and Inverse-Electron-Demand Diels–Alder Chemistry: A Convenient Radioiodination Strategy for Biomolecule Labeling, Screening, and Biodistribution Studies. Bioconjugate Chemistry. 27:207-216. 2016
- A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS ONE. 11:e0167425-e0167425. 2016
- Imaging Biomarkers in Immunotherapy. Biomarkers in Cancer. 8s2:BIC.S31805-BIC.S31805. 2016
- Reprint of: Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions. Journal of Organometallic Chemistry. 798:278-288. 2015
- Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions. Journal of Organometallic Chemistry. 798:289-289. 2015
- Synthesis, Radiolabeling, and In Vivo Imaging of PEGylated High-Generation Polyester Dendrimers. Biomacromolecules. 16:3033-3041. 2015
- Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions. Journal of Organometallic Chemistry. 791:204-213. 2015
- Fluorous Analogue of Chloramine-T: Preparation, X-ray Structure Determination, and Use as an Oxidant for Radioiodination and s-Tetrazine Synthesis. Journal of Organic Chemistry. 80:7117-7125. 2015
- 125I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells. Nuclear Medicine and Biology. 42:274-282. 2015
- Imidazole-Based [2 + 1] Re(I)/^99mTc(I) Complexes as Isostructural Nuclear and Optical Probes. Inorganic Chemistry. 54:1728-1736. 2015
- Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B. Journal of Medicinal Chemistry. 57:9564-9577. 2014
- Large-scale cyclotron production of 99mTc. Nuclear Medicine and Biology. 41:647-647. 2014
- A hybrid solid‐fluorous phase radioiodination and purification platform. Journal of Labelled Compounds and Radiopharmaceuticals. 57:551-557. 2014
- Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse‐Electron‐Demand Diels–Alder Reactions. Angewandte Chemie International Edition. 126:6577-6581. 2014
- Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse‐Electron‐Demand Diels–Alder Reactions. Angewandte Chemie International Edition. 53:6459-6463. 2014
- Implementation of Multi-Curie Production of ^99mTc by Conventional Medical Cyclotrons. Journal of Nuclear Medicine. 55:1017-1022. 2014
- High Yielding Synthesis of Carboranes Under Mild Reaction Conditions Using a Homogeneous Silver(I) Catalyst: Direct Evidence of a Bimetallic Intermediate. Angewandte Chemie International Edition. 126:5256-5260. 2014
- High Yielding Synthesis of Carboranes Under Mild Reaction Conditions Using a Homogeneous Silver(I) Catalyst: Direct Evidence of a Bimetallic Intermediate. Angewandte Chemie International Edition. 53:5156-5160. 2014
- Preparation and Evaluation of Fluorine-18-Labeled Insulin as a Molecular Imaging Probe for Studying Insulin Receptor Expression in Tumors. Journal of Medicinal Chemistry. 57:3678-3686. 2014
- Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA). Dalton Transactions. 43:4950-4961. 2014
- Single amino acid chelate complexes of the M(CO)₃⁺ core for correlating fluorescence and radioimaging studies (M = ^99mTc or Re). Journal of Labelled Compounds and Radiopharmaceuticals. 57:255-261. 2014
- Isostructural Nuclear and Luminescent Probes Derived From Stabilized [2 + 1] Rhenium(I)/Technetium(I) Organometallic Complexes. Inorganic Chemistry. 52:13521-13528. 2013
- High Yielding Preparation of Dicarba-closo-dodecaboranes Using a Silver(I) Mediated Dehydrogenative Alkyne-Insertion Reaction. Inorganic Chemistry. 52:8743-8749. 2013
- Emission wavelength variation with changes in excitation in a Re(i)–bisthiazole ligand complex that breaks the Kasha–Vavilov rule. Chemical Science. 4:2490-2490. 2013
- Room-Temperature Synthesis of Re(I) and Tc(I) Metallocarboranes. Organometallics. 31:5940-5949. 2012
- Synthesis, Characterisation, and Biodistribution of Radioiodinated C‐Hydroxy‐Carboranes. Chemistry - A European Journal. 18:11071-11078. 2012
- The preparation and characterization of functionalized carboranes and Re/Tc-metallocarboranes as platforms for developing molecular imaging probes: Structural and cage isomerism studies. Inorganica Chimica Acta. 389:159-167. 2012
- Emulsion Reactors: A New Technique for the Preparation of Molecular Imaging Probes. Chemistry - A European Journal. 18:6746-6749. 2012
- Triazole Appending Agent (TAAG): A New Synthon for Preparing Iodine-Based Molecular Imaging and Radiotherapy Agents. ACS Medicinal Chemistry Letters. 3:313-316. 2012
- Preface. Pure and Applied Chemistry. 84:iv-iv. 2012
- Preparation of technetium‐99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods. Journal of Labelled Compounds and Radiopharmaceuticals. 55:18-22. 2012
- Correction to Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors. Journal of Medicinal Chemistry. 54:8712-8712. 2011
- fac‐[TcO₃(tacn)]⁺: A Versatile Precursor for the Labelling of Pharmacophores, Amino Acids and Carbohydrates through a New Ligand‐Centred Labelling Strategy. Chemistry - A European Journal. 17:12967-12974. 2011
- The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles. Nuclear Medicine and Biology. 38:1111-1118. 2011
- 99mTc-Based Imaging of Transplanted Neural Stem Cells and Progenitor Cells. Journal of Nuclear Medicine Technology. 39:114-120. 2011
- Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors. Journal of Medicinal Chemistry. 54:3360-3367. 2011
- Preparation and evaluation of reagents for tagging amino and thiol groups with fluorous stannanes. A convenient method for producing radioiodinated compounds in high effective specific activity. Journal of Labelled Compounds and Radiopharmaceuticals. 54:65-71. 2011
- Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity. Chemical Communications. 47:7518-7518. 2011
- Preparation and Evaluation of Carborane Analogues of Tamoxifen. Journal of Medicinal Chemistry. 53:8012-8020. 2010
- N-(4-Methoxyphenyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea. Acta Crystallographica Section E. 66:o2339-o2339. 2010
- A bridge not too far: linking disciplines through molecular imaging probes.. Journal of Nuclear Medicine. 51:1258-1268. 2010
- Technetium and Gallium Derived Radiopharmaceuticals: Comparing and Contrasting the Chemistry of Two Important Radiometals for the Molecular Imaging Era. Chemical Reviews. 110:2903-2920. 2010
- Synthesis and Characterization of Rhenium and Technetium-99m Labeled Insulin. Journal of Medicinal Chemistry. 53:2612-2621. 2010
- Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(i) and Tc(i) carborane complexes. Dalton Transactions. 39:8128-8128. 2010
- Fluorous Isocyanates: Convenient Synthons for the Preparation of Radioiodinated Compounds in High Effective Specific Activity. Journal of Organic Chemistry. 74:8133-8138. 2009
- Evaluation of single amino acid chelate derivatives and regioselective radiolabelling of a cyclic peptide for the urokinase plasminogen activator receptor. Nuclear Medicine and Biology. 36:907-917. 2009
- Comprehensive Radiolabeling, Stability, and Tissue Distribution Studies of Technetium-99m Single Amino Acid Chelates (SAAC). Bioconjugate Chemistry. 20:1625-1633. 2009
- ChemInform Abstract: Single Amino Acid Chelates (SAAC): A Strategy for the Design of Technetium and Rhenium Radiopharmaceuticals. ChemInform. 40:no-no. 2009
- Functionalized Carborane Complexes of the [M(CO)₂(NO)]²⁺ Core (M = ^99mTc, Re): A New Class of Organometallic Probes for Correlated in Vitro and in Vivo Imaging. Organometallics. 28:2986-2992. 2009
- Synthesis and screening of bifunctional radiolabelled carborane-carbohydrate derivatives. Journal of Organometallic Chemistry. 694:1736-1746. 2009
- ChemInform Abstract: A Convenient Method for the Preparation of Fluorous Tin Derivatives for the Fluorous Labeling Strategy.. ChemInform. 40:no-no. 2009
- Synthesis, Radiolabeling, and Bio-imaging of High-Generation Polyester Dendrimers. Journal of the American Chemical Society. 131:2906-2916. 2009
- Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals. Chemical Communications. 0:493-512. 2009
- A Convenient Method for the Preparation of Fluorous Tin Derivatives for the Fluorous Labeling Strategy. Journal of Organic Chemistry. 73:8236-8243. 2008
- Carborane-carbohydrate derivatives — Versatile platforms for developing targeted radiopharmaceuticals. Canadian Journal of Chemistry. 86:1063-1069. 2008
- A convenient solution-phase method for the preparation of meta-iodobenzylguanidine in high effective specific activity. Nuclear Medicine and Biology. 35:741-746. 2008
- Expedient Multi-Step Synthesis of Organometallic Complexes of Tc and Re in High Effective Specific Activity. A New Platform for the Production of Molecular Imaging and Therapy Agents. Inorganic Chemistry. 47:8213-8221. 2008
- Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor. Journal of Medicinal Chemistry. 51:2833-2844. 2008
- Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides. Bioconjugate Chemistry. 19:1087-1094. 2008
- ChemInform Abstract: The Bioinorganic and Medicinal Chemistry of Carboranes — From New Drug Discovery to Molecular Imaging and Therapy. ChemInform. 39:no-no. 2008
- Isostructural fluorescent and radioactive probes for monitoring neural stem and progenitor cell transplants. Nuclear Medicine and Biology. 35:159-169. 2008
- A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents. Chemical Communications. 0:5532-5532. 2008
- Justifying the number of animals for each experiment. Nuclear Medicine and Biology. 34:229-232. 2007
- Microwave-Assisted Synthesis of Tricarbonyl Rhenacarboranes: Steric and Electronic Effects on the 1,2 → 1,7 Carborane Cage Isomerization. Inorganic Chemistry. 46:2148-2158. 2007
- The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy. Dalton Transactions. 0:4240-4240. 2007
- Microwave-Assisted Synthesis of 3,1,2- and 2,1,8-Re(I) and ^99mTc(I)−Metallocarborane Complexes. Inorganic Chemistry. 45:5727-5729. 2006
- Thermally Induced Phase Transition of Carborane-Functionalized Aliphatic Polyester Dendrimers in Aqueous Media. Langmuir. 22:5251-5255. 2006
- Extension of the Single Amino Acid Chelate Concept (SAAC) to Bifunctional Biotin Analogues for Complexation of the M(CO)₃⁺¹ Core (M = Tc and Re): Syntheses, Characterization, Biotinidase Stability, and Avidin Binding. Bioconjugate Chemistry. 17:579-589. 2006
- Isostructural Re and ^99mTc Complexes of Biotin Derivatives for Fluorescence and Radioimaging Studies. Bioconjugate Chemistry. 17:590-596. 2006
- A New Strategy for Preparing Molecular Imaging and Therapy Agents Using Fluorine-Rich (Fluorous) Soluble Supports. Journal of the American Chemical Society. 128:3536-3537. 2006
- Synthesis and in Vitro Evaluation of¹⁸F- and¹⁹F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies. Journal of Medicinal Chemistry. 49:1466-1474. 2006
- A Solid-Phase Labeling Strategy for the Preparation of Technetium and Rhenium Bifunctional Chelate Complexes and Associated Peptide Conjugates. Bioconjugate Chemistry. 17:226-235. 2006
- New Directions in the Coordination Chemistry of 99mTc: A Reflection on Technetium Core Structures and a Strategy for New Chelate Design. ChemInform. 36:no-no. 2005
- A convenient solid-phase synthesis methodology for preparing peptide-derived molecular imaging agents Synthesis, characterization, and in vitro screening of Tc(I) chemotactic peptide conjugates. Canadian Journal of Chemistry. 83:2060-2066. 2005
- Aqueous Fluoride and the Preparation of [^99mTc(CO)₃(OH₂)₃]⁺ and ^99mTc−Carborane Complexes. Inorganic Chemistry. 44:9585-9591. 2005
- Synthesis of Ortho- and Meta-Re(I)-Metallocarboranes in Water. Inorganic Chemistry. 44:9574-9584. 2005
- A New Strategy for the Preparation of Peptide-Targeted Technetium and Rhenium Radiopharmaceuticals. The Automated Solid-Phase Synthesis, Characterization, Labeling, and Screening of a Peptide-Ligand Library Targeted at the Formyl Peptide Receptor. Bioconjugate Chemistry. 16:1189-1195. 2005
- Thiol- and Thioether-Based Bifunctional Chelates for the {M(CO)₃}⁺ Core (M = Tc, Re). Inorganic Chemistry. 44:6763-6770. 2005
- Synthesis and Properties of Carborane-Functionalized Aliphatic Polyester Dendrimers. Journal of the American Chemical Society. 127:12081-12089. 2005
- N,N-Bis(2-mercaptoethyl)methylamine: A New Coligand for Tc-99m Labeling of Hydrazinonicotinamide Peptides. Bioconjugate Chemistry. 16:885-902. 2005
- Design and synthesis of site directed maleimide bifunctional chelators for technetium and rhenium. Dalton Transactions. 0:3886-3886. 2005
- New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design. Nuclear Medicine and Biology. 32:1-20. 2005
- Bridging the Gap between in Vitro and in Vivo Imaging: Isostructural Re and^99mTc Complexes for Correlating Fluorescence and Radioimaging Studies. Journal of the American Chemical Society. 126:8598-8599. 2004
- Preparation of Re(I)− and ^99mTc(I)−Metallocarboranes in Water under Weakly Basic Reaction Conditions. Inorganic Chemistry. 43:3032-3034. 2004
- Sterically Hindered and Robust Pnictogen Ligands Derived from Carboranes: Synthesis and X-ray Structure Determination of Tris(1‘-methyl(1,2-dicarba-closo-dodecaboran-1-yl))phosphine, Tris(1‘-methyl(1,2-dicarba-closo-dodecaboran-1-yl))arsine and Chloro(Tris(1‘-methyl(1,2-dicarba-closo-dodecaboran-1-yl))phosphine)gold(I). Inorganic Chemistry. 43:3507-3513. 2004
- Determination of Strong Ligand Sites in Sewage Effluent-Impacted Waters by Competitive Ligand Titration with Silver. Environmental Science and Technology. 38:2120-2125. 2004
- A New Strategy for the Preparation of Peptide-Targeted Radiopharmaceuticals Based on an Fmoc-Lysine-Derived Single Amino Acid Chelate (SAAC). Automated Solid-Phase Synthesis, NMR Characterization, and in Vitro Screening of fMLF(SAAC)G and fMLF[(SAAC−Re(CO)₃)⁺]G. Bioconjugate Chemistry. 15:128-136. 2004
- Synthesis of homoleptic Re(I) complexes of isocyano-carboranes and the X-ray structure of hexakis(p-carboran-1-yl-isonitrile)Re(I). Journal of Organometallic Chemistry. 680:323-328. 2003
- Solvent–metal interactions in bis[1,2-dicarba-closo-dodecaboran(12)-1-yl]mercury(II) dichloromethane solvate and bis[1,12-dicarba-closo-dodecaboran(12)-1-yl]mercury(II) tetrahydrofuran solvate. Acta Crystallographica Section C: Crystal Structure Communications. 58:m601-m604. 2002
- Bifunctional Single Amino Acid Chelates for Labeling of Biomolecules with the {Tc(CO)₃}⁺and {Re(CO)₃}⁺Cores. Crystal and Molecular Structures of [ReBr(CO)₃(H₂NCH₂C₅H₄N)], [Re(CO)₃{(C₅H₄NCH₂)₂NH}]Br, [Re(CO)₃{(C₅H₄NCH₂)₂NCH₂CO₂H}]Br, [Re(CO)₃{X(Y)NCH₂CO₂CH₂CH₃}]Br (X = Y = 2-pyridylmethyl; X = 2-pyridylmethyl, Y = 2-(1-methylimidazolyl)methyl; X = Y = 2-(1-methylimidazolyl)methyl), [ReBr(CO)₃{(C₅H₄NCH₂)NH(CH₂C₄H₃S)}], and [Re(CO)₃{(C₅H₄NCH₂)N(CH₂C₄H₃S)(CH₂CO₂)}]. Inorganic Chemistry. 41:6417-6425. 2002
- Unexpected Formation of an Azetidine−Carborane Derivative by Dehydration of N-(1,12-Dicarba-closo-dodecaboran-1-yl)formamide. The First X-ray Structure of a 2,3-Bis(imino)azetidine. Inorganic Chemistry. 41:6493-6499. 2002
- {Re^IIICl₃} Core Complexes with Bifunctional Single Amino Acid Chelates. Inorganic Chemistry. 41:5795-5802. 2002
- The medicinal chemistry of carboranes. Coordination Chemistry Reviews. 232:173-230. 2002
- Colloidal Flocculation with Poly(ethylene oxide)/Polypeptide Complexes. Langmuir. 18:4536-4538. 2002
- Synthesis, NMR, and X-ray Crystallographic Analysis of C-Hydrazino-C-Carboxycarboranes: Versatile Ligands for the Preparation of BNCT and BNCS Agents and ^99mTc Radiopharmaceuticals. Inorganic Chemistry. 41:2731-2737. 2002
- Carboranes as Ligands for the Preparation of Organometallic Tc and Re Radiopharmaceuticals. Synthesis of [M(CO)₃(η⁵-2,3-C₂B₉H₁₁)]^- and rac-[M(CO)₃(η⁵-2-R-2,3-C₂B₉H₁₀)]^- (M = Re, ⁹⁹Tc; R = CH₂CH₂CO₂H) from [M(CO)₃Br₃]^2-. Inorganic Chemistry. 41:628-630. 2002
- Synthesis of Boroxifen, A Nido-Carborane Analogue of Tamoxifen. Journal of Organic Chemistry. 67:383-387. 2002
- The solid phase synthesis and NMR spectroscopy of a 99Tc chelate–bombesin derived peptide conjugate. Inorganica Chimica Acta. 325:155-163. 2001
- A new approach for the synthesis of isonitrile carborane derivatives.. Journal of Inorganic Biochemistry. 85:43-51. 2001
- Two approaches for the syntheis of carbon‐11 labeled (R) and (S)‐albuterol. Journal of Labelled Compounds and Radiopharmaceuticals. 44:s134-s136. 2001
- The synthesis of corticosteroid–carborane esters for the treatment of rheumatoid arthritis via boron neutron capture synovectomy. Tetrahedron Letters. 41:1355-1358. 2000
- NMR studies of chemical exchange amongst five conformers of a ten-membered ring compound containing two amide bonds and a disulfide †. Journal of the Chemical Society, Perkin Transactions 2. 0:1447-1454. 1999
- The total synthesis of a technetium chelate - tamoxifen complex. Canadian Journal of Chemistry. 77:146-154. 1999
- The Synthesis, NMR Spectroscopy, and X-ray Structure of a New Rhenium N₂S₂ Chelate Complex. Inorganic Chemistry. 37:3517-3520. 1998
- The synthesis, NMR and X-ray analysis of tris(1-ethyl-2-isopropylimidazol-5-yl)phosphine gold (I)-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside, a bifunctional auranofin analogue. Inorganica Chimica Acta. 274:137-142. 1998
- Rhenium(V) and Technetium(V) Oxo Complexes of an N₂N‘S Peptidic Chelator: Evidence of Interconversion between theSynandAntiConformations. Inorganic Chemistry. 36:5799-5808. 1997
- Tetrakis(cyclopentamethylenedithiocarbamate-S,S ′)technetium(v) bromide, an unusual eight-coordinate complex of technetium(v). Chemical Communications. 0:585-586. 1997
- The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2″′-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: a chelate–chlorambucil complex for use as a ligand for ^99mTc radio-imaging. Canadian Journal of Chemistry. 74:1503-1511. 1996
- The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-{4′-[4″-(1″-bis(2‴- chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine: A chelate-chlorambucil complex for use as a ligand for ^99mTc radio-imaging. Canadian Journal of Chemistry. 74:1502-1511. 1996
- Preparation and Evaluation of <sup>99m</sup>Tc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry. Journal of Visualized Experiments.
preprints