Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry Academic Article uri icon

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abstract

  • A new 99mTc-labelled tetrazine for targeted imaging using bioorthogonal chemistry was developed and evaluated in vivo using a trans-cyclooctene derived bisphosphonate targeting regions of high bone turnover and bone lesions.

authors

  • Yazdani, Abdolreza
  • Janzen, Nancy
  • Czorny, Shannon
  • Ungard, Robert G
  • Miladinovic, Tanya
  • Singh, Gurmit
  • Valliant, John F

publication date

  • October 31, 2017