Preparation of tetrazine-containing [2 + 1] complexes of ^99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry Academic Article

A new ^99mTc-labelled tetrazine for targeted imaging using bioorthogonal chemistry was developed and evaluated in vivo using a trans-cyclooctene derived bisphosphonate targeting regions of high bone turnover and bone lesions.