Journal article
Infectious circular DNA of human adenovirus type 5: regeneration of viral DNA termini from molecules lacking terminal sequences.
Abstract
A series of plasmids containing the entire human adenovirus genome with viral DNA termini joined ‘head to tail’ has been isolated. Several plasmids were able to generate infectious virus following transfection of human cells in spite of having small deletions and rearrangements at the junctions of termini. One plasmid has lost 2 bp of DNA from one end of the viral genome and 11 bp from the other end yet produced viruses with complete wild‐type …
Authors
Graham FL; Rudy J; Brinkley P
Journal
The EMBO Journal, Vol. 8, No. 7, pp. 2077–2085
Publisher
Springer Nature
Publication Date
July 1989
DOI
10.1002/j.1460-2075.1989.tb03616.x
ISSN
0261-4189