Journal article
Immune response to HIV-1 gag antigens induced by recombinant adenovirus vectors in mice and rhesus macaque monkeys.
Abstract
Recombinant adenovirus vectors expressing the entire gag (p55) or CA (p24) region of human immunodeficiency virus type 1 (HIV-1) were constructed by inserting the appropriate HIV DNA sequences into the E3 region of human adenovirus type 5 (Ad5) with and without an exogenous SV40 early promoter. The infectious recombinant adenoviruses Adgag1, AdSVgag1, and AdSVCA1 were shown to express the appropriate HIV-1 antigens in human cells in vitro, as …
Authors
Prevec L; Christie BS; Laurie KE; Bailey MM; Graham FL; Rosenthal KL
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol. 4, No. 6, pp. 568–576
Publication Date
1991
ISSN
1525-4135