Journal article
Protective Immunity to Rotavirus-Induced Diarrhoea Is Passively Transferred to Newborn Mice from Naive Dams Vaccinated with a Single Dose of a Recombinant Adenovirus Expressing Rotavirus VP7sc
Abstract
VP7sc is a novel rotavirus antigen engineered for presentation at the cell surface. Several recombinant viruses were constructed in which VP7sc was inserted into the E3 region of the human type 5 adenovirus (Ad5) genome and expression and transport of the antigen was monitored in cultured 293 cells. The recombinant virus showing the greatest level of expression (Ad5/7.4) was then used to determine whether antibodies to VP7sc could be induced in …
Authors
Both GW; Lockett LJ; Janardhana V; Edwards SJ; Bellamy AR; Graham FL; Prevec L; Andrew ME
Journal
Virology, Vol. 193, No. 2, pp. 940–950
Publisher
Elsevier
Publication Date
April 1993
DOI
10.1006/viro.1993.1203
ISSN
0042-6822
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenoviruses, HumanAnimalsAnimals, NewbornAntibodies, ViralAntigens, ViralCapsidCapsid ProteinsCell LineCloning, MolecularDiarrheaFemaleHumansImmunity, Maternally-AcquiredImmunization, PassiveMaleMiceMice, Inbred BALB CMice, Inbred CBAPregnancyRecombinant ProteinsRestriction MappingRotavirusRotavirus InfectionsVaccines, SyntheticViral Vaccines