Journal article
Mouse hepatitis virus spike and nucleocapsid proteins expressed by adenovirus vectors protect mice against a lethal infection
Abstract
Infection with the mouse hepatitis coronavirus (MHV) provides an excellent model for the study of viral diseases of the central nervous system and the gastrointestinal tract. With the ultimate aim of studying mucosal immunity to MHV we have cloned the genes encoding the structural proteins of MHV strain A59 (MHV-A59) into the E3 region of a human adenovirus type 5 vector. Infection of HeLa cells with the resulting recombinant adenoviruses …
Authors
Wesseling JG; Godeke GJ; Schijns VE; Prevec L; Graham FL; Horzinek MC; Rottier PJ
Journal
Journal of General Virology, Vol. 74, No. 10, pp. 2061–2069
Publisher
Microbiology Society
Publication Date
October 1, 1993
DOI
10.1099/0022-1317-74-10-2061
ISSN
0022-1317
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Adenoviruses, HumanAnimalsAntibodies, ViralCapsidCloning, MolecularCoronavirus InfectionsFemaleGenes, ViralGenetic VectorsHeLa CellsHepatitis, Viral, AnimalHumansMembrane GlycoproteinsMiceMice, Inbred BALB CMurine hepatitis virusRecombination, GeneticSpike Glycoprotein, CoronavirusViral Core ProteinsViral Envelope Proteins