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Genome-wide association study identifies a novel...
Journal article

Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth

Abstract

BackgroundMaternal stress is potentially a modifiable risk factor for spontaneous preterm birth (sPTB). However, epidemiologic findings on the maternal stress−sPTB relationship have been inconsistent.MethodsTo investigate whether the maternal stress−sPTB associations may be modified by genetic susceptibility, we performed genome-wide gene × stress interaction analyses in 1490 African-American women from the Boston Birth cohort who delivered …

Authors

Hong X; Surkan PJ; Zhang B; Keiser A; Ji Y; Ji H; Burd I; Bustamante-Helfrich B; Ogunwole SM; Tang W-Y

Journal

Pediatric Research, Vol. 89, No. 6, pp. 1549–1556

Publisher

Springer Nature

Publication Date

May 2021

DOI

10.1038/s41390-020-1093-1

ISSN

0031-3998