Detection of Changes in Blood Glucose Concentration in vivo with Spatially Resolved Diffuse Reflectance

Diabetics would benefit from a device capable of providing continuous non-invasive monitoring of their blood glucose levels. A feasibility study was performed to determine whether a technique applying spatially resolved diffuse reflectance measurements could be used to detect changes in the blood glucose levels of diabetic volunteers by monitoring the tissue reduced scattering coefficient. A correlation was observed between step changes in blood glucose concentration and tissue reduced scattering coefficient in 17 out of 22 subjects. A study on non-diabetic volunteers was used to estimate the physiological baseline noise level.