Journal article
Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions
Abstract
The conserved hemagglutinin stalk domain is an attractive target for broadly effective antibody-based therapeutics and next-generation universal influenza vaccines. Protection provided by hemagglutinin stalk-binding antibodies is principally mediated through activation of immune effector cells. Titers of stalk-binding antibodies are highly variable on an individual level and tend to increase with age as a result of increasing exposures to …
Authors
Zhang A; Chaudhari H; Agung Y; D’Agostino MR; Ang JC; Tugg Y; Miller MS
Journal
Cell Reports Medicine, Vol. 3, No. 8,
Publisher
Elsevier
Publication Date
August 2022
DOI
10.1016/j.xcrm.2022.100718
ISSN
2666-3791