Journal article
Folding Regulates Autoprocessing of HIV-1 Protease Precursor*
Abstract
Autoprocessing of HIV-1 protease (PR) precursors is a crucial step in the generation of the mature protease. Very little is known regarding the molecular mechanism and regulation of this important process in the viral life cycle. In this context we report here the first and complete residue level investigations on the structural and folding characteristics of the 17-kDa precursor TFR-PR-C(nn) (161 residues) of HIV-1 protease. The precursor …
Authors
Chatterjee A; Mridula P; Mishra RK; Mittal R; Hosur RV
Journal
Journal of Biological Chemistry, Vol. 280, No. 12, pp. 11369–11378
Publisher
Elsevier
Publication Date
March 2005
DOI
10.1074/jbc.m412603200
ISSN
0021-9258