published in ADVANCES IN STATISTICAL METHODS FOR THE HEALTH SCIENCES: APPLICATIONS TO CANCER AND AIDS STUDIES, GENOME SEQUENCE ANALYSIS, AND SURVIVAL ANALYSIS Journal
keywords CLINICAL-TRIALS Life Sciences & Biomedicine Mathematics Mathematics, Interdisciplinary Applications Monte Carlo simulations Physical Sciences Public, Environmental & Occupational Health REGRESSION Science & Technology Statistics & Probability clinical trials isotonic regression estimators maximum likelihood estimator maximum tolerated dose robustness sequential adaptive designs