Journal article
An Evaluation of Cardiac Health in the Spontaneously Hypertensive Rat Colony: Implications of Evolutionary Driven Increases in Concentric Hypertrophy
Abstract
BACKGROUND: The Spontaneously Hypertensive Rat (SHR) Colony was established in 1963 and is the most commonly used rodent model for studying heart failure (HF). Ideally, animal models should recapitulate the clinical disease as closely as possible. Any drift in a genetic model may create a new model that no longer adequately represents the human pathology. Further, instability overtime may lead to conflicting data between laboratories and/or …
Authors
Holjak EJB; Savinova I; Nelson VL; Ogilvie LM; Ng AM; Edgett BA; Platt MJ; Brunt KR; Ask K; Simpson JA
Journal
American Journal of Hypertension, Vol. 35, No. 3, pp. 264–271
Publisher
Oxford University Press (OUP)
Publication Date
March 8, 2022
DOI
10.1093/ajh/hpab155
ISSN
0895-7061