Journal article
IMMU-03. THERAPEUTIC TARGETING OF TUMORIGENICEphA2+/EphA3+ BRAIN TUMOR INITIATING CELLS WITH BISPECIFIC ANTIBODY IN HUMAN GLIOBLASTOMA
Abstract
Human glioblastoma (hGBM) carries a dismal prognosis and inevitably relapses despite aggressive therapy. Many of the 14 members of the Eph receptor tyrosine kinase family are expressed in hGBM initiating cells (GICs) and constitute potential molecular targets. We hypothesize that multiple members of the EphR family play a critical role in hGBM recurrence. Using a highly specific human EphR antibody panel, we identified differential expression …
Authors
Qazi M; Vora P; Venugopal C; Gorelik M; Singh M; Hu A; Subapanditha M; Chokshi C; Savage N; Yelle N
Journal
Neuro-Oncology, Vol. 19, No. suppl_6, pp. vi113–vi113
Publisher
Oxford University Press (OUP)
Publication Date
November 6, 2017
DOI
10.1093/neuonc/nox168.462
ISSN
1522-8517