Journal article
Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study
Abstract
BACKGROUND: Serum neurofilament light chain (sNfL) is a biomarker of neuronal damage that is used not only to monitor disease activity and response to drugs and to prognosticate disease course in people with multiple sclerosis on the group level. The absence of representative reference values to correct for physiological age-dependent increases in sNfL has limited the diagnostic use of this biomarker at an individual level. We aimed to assess …
Authors
Benkert P; Meier S; Schaedelin S; Manouchehrinia A; Yaldizli Ö; Maceski A; Oechtering J; Achtnichts L; Conen D; Derfuss T
Journal
The Lancet Neurology, Vol. 21, No. 3, pp. 246–257
Publisher
Elsevier
Publication Date
March 2022
DOI
10.1016/s1474-4422(22)00009-6
ISSN
1474-4422