Journal article
FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells
Abstract
Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells overexpressing hIAPP, cell fractionation studies revealed increased accumulation of hIAPP. Unexpectedly, a significant fraction (up to 22%) of hIAPP was found in the nuclear soluble and chromatin-enriched fractions of cultured human islet and …
Authors
Bhowmick DC; Burnett L; Kudaibergenova Z; Jeremic AM
Journal
Biochemical Journal, Vol. 478, No. 6, pp. 1261–1282
Publisher
Portland Press
Publication Date
March 26, 2021
DOI
10.1042/bcj20200984
ISSN
0264-6021