Journal article
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity
Abstract
Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK have been developed and are effective in mice but have suboptimal specificity and sensitivity in humans. To identify a more suitable probe for clinical dCK PET imaging, we compared the selectivity of two candidate …
Authors
Kim W; Le TM; Wei L; Poddar S; Bazzy J; Wang X; Uong NT; Abt ER; Capri JR; Austin WR
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 15, pp. 4027–4032
Publisher
Proceedings of the National Academy of Sciences
Publication Date
April 12, 2016
DOI
10.1073/pnas.1524212113
ISSN
0027-8424