Journal article
Host Genetic Determinants Associated With Helicobacter pylori Eradication Treatment Failure: A Systematic Review and Meta-analysis
Abstract
BACKGROUND & AIMS: Helicobacter pylori infects approximately 50% of individuals worldwide. Successful H pylori eradication is associated with reduced risk of gastric cancer and peptic ulcer disease, among other conditions. We hypothesized that host genetic determinants, especially those affecting gastric pH, might contribute to eradication therapy failure, particularly when treatment adherence and antibiotic susceptibility are confirmed. We …
Authors
Shah SC; Tepler A; Chung CP; Suarez G; Peek RM; Hung A; Roumie C; Narula N
Journal
Gastroenterology, Vol. 161, No. 5, pp. 1443–1459
Publisher
Elsevier
Publication Date
November 2021
DOI
10.1053/j.gastro.2021.07.043
ISSN
0016-5085
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily BAdultAgedAged, 80 and overAnti-Bacterial AgentsCytochrome P-450 CYP2C19Drug Resistance, BacterialFemaleHelicobacter InfectionsHelicobacter pyloriHumansInterleukin-1betaMaleMiddle AgedPharmacogeneticsPharmacogenomic TestingPharmacogenomic VariantsPolymorphism, Single NucleotidePredictive Value of TestsProton Pump InhibitorsRisk AssessmentRisk FactorsTreatment FailureYoung Adult