Journal article
Investigation of Blood-Brain Barrier Disruption in an Animal Model of Mania Induced by d-Amphetamine
Abstract
Background: Bipolar disorder (BD) is a recurrent chronic psychiatric disorder. Evidence indicates that many individuals with BD exhibit high serum levels of inflammation and oxidative stress markers, which are further associated with mood symptoms and cognitive dysfunction. Due to the crosstalk between the periphery and central nervous system in BD, the disruption of the blood-brain barrier (BBB) has been proposed as a key mechanism of the …
Authors
Géa LP; Wollenhaupt-Aguiar B; Watts D; Maich W; Kapczinski F; Sharma R; Mishra R; Rosa AR; Frey BN
Journal
, , ,
Publisher
Research Square Platform
DOI
10.21203/rs.3.rs-929977/v1
ISSN
2693-5015