Journal article
Searching for Substitution Rate Heterogeneity
Abstract
A permutation method for detecting regional substitution rate heterogeneity in DNA sequences is described. An estimated phylogeny for the sequences is required. The method is likelihood based and searches through all regions of a DNA sequence to find any regions that have an unusually large (or small) number of substitutions in comparison to an optimal substitution rate for the entire sequence. Likelihood ratio tests do not achieve proper …
Authors
Hartmann M; Golding GB
Journal
Molecular Phylogenetics and Evolution, Vol. 9, No. 1, pp. 64–71
Publisher
Elsevier
Publication Date
February 1998
DOI
10.1006/mpev.1997.0446
ISSN
1055-7903