Journal article
Helper-Dependent Adenoviral Vectors Containing Modified Fiber for Improved Transduction of Developing and Mature Muscle Cells
Abstract
Adenoviruses (Ads) have shown great utility as vectors for the delivery of genes to mammalian cells, partly because of their ability to infect a wide range of different cell types independent of the replicative state of the cell. However, Ads do not transduce mature muscle efficiently because of low levels of the natural viral primary receptor, the coxsackie virus and adenovirus receptor, on the surface of adult muscle cells. In this study, we …
Authors
Bramson JL; Grinshtein N; Meulenbroek RA; Lunde J; Kottachchi D; Lorimer IA; Jasmin BJ; Parks RJ
Journal
Human Gene Therapy, Vol. 15, No. 2, pp. 179–188
Publisher
Mary Ann Liebert
Publication Date
February 2004
DOI
10.1089/104303404772679986
ISSN
1043-0342