T-cell immunity generated by recombinant adenovirus vaccines Academic Article uri icon

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  • Recombinant adenovirus vaccines show great promise for generating protective immunity against infectious agents and tumors. Our studies have identified several interesting biological features of the adenovirus vector that influence the T-cell response. Notably, we have demonstrated that following immunization with adenovirus vaccines, the transgene antigen remains available to the system for a longer period than would be expected, resulting in a T-cell population with a sustained effector phenotype. The implications of these observations with regards to the utility of adenovirus vaccines are discussed.


  • Yang, Teng Chih
  • Millar, James B
  • Grinshtein, Natalie
  • Bassett, Jennifer
  • Finn, Jonathan
  • Bramson, Jonathan

publication date

  • June 2007