State-selective frustration as a key driver of allosteric pluripotency Academic Article uri icon

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abstract

  • The Rp-cAMPS ligand of protein kinase A switches from agonist to antagonist depending on metabolite and proteomic contexts. We show that the state-selective frustration is a key driver of this allosteric pluripotency phenomenon.

authors

  • Byun, Jung Ah
  • VanSchouwen, Bryan
  • Parikh, Nishi
  • Akimoto, Madoka
  • McNicholl, Eric Tyler
  • Melacini, Giuseppe

publication date

  • September 2021