Conference
B16 melanoma inhibits cellular response to Interleukin-12 via multiple mechanisms including paracrine action of Wnt-inducible Signaling Protein-1 (46.10)
Abstract
Abstract Interleukin-12 (IL12) enhances anti-tumor immunity when delivered locally within the tumor microenvironment. However, immunoregulatory elements within the tumor microenvironment are thought to dampen the effect of IL12 as an adjuvant. The objective of this study was to identify biochemical mechanisms of tumor-immune cell cross-talk that locally suppress the action of IL12. A high content in vitro assay was developed to quantify …
Authors
Klinke D; Kulkarni Y; Chambers E; McGray AJR; Ware J; Bramson J
Volume
188
Pagination
pp. 46.10-46.10
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2012
DOI
10.4049/jimmunol.188.supp.46.10
Conference proceedings
The Journal of Immunology
Issue
1_Supplement
ISSN
0022-1767