Journal article
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis
Abstract
Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem counterproductive. We developed a treatment for melanomas by pre-vaccinating against an oncolytic vesicular stomatitis virus (VSV)-encoded tumor antigen. Surprisingly, when the VSV-vectored …
Authors
AuYeung AWK; Mould RC; Stegelmeier AA; van Vloten JP; Karimi K; Woods JP; Petrik JJ; Wood GA; Bridle BW
Journal
Scientific Reports, Vol. 11, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-021-94483-z
ISSN
2045-2322