Journal article
Isoosmolar Enemas Demonstrate Preferential Gastrointestinal Distribution, Safety, and Acceptability Compared with Hyperosmolar and Hypoosmolar Enemas as a Potential Delivery Vehicle for Rectal Microbicides
Abstract
Rectally applied antiretroviral microbicides for preexposure prophylaxis (PrEP) of HIV infection are currently in development. Since enemas (rectal douches) are commonly used by men who have sex with men prior to receptive anal intercourse, a microbicide enema could enhance PrEP adherence by fitting seamlessly within the usual sexual practices. We assessed the distribution, safety, and acceptability of three enema types-hyperosmolar (Fleet), …
Authors
Leyva FJ; Bakshi RP; Fuchs EJ; Li L; Caffo BS; Goldsmith AJ; Ventuneac A; Carballo-Diéguez A; Du Y; Leal JP
Journal
AIDS Research and Human Retroviruses, Vol. 29, No. 11, pp. 1487–1495
Publisher
Mary Ann Liebert
Publication Date
November 2013
DOI
10.1089/aid.2013.0189
ISSN
0889-2229