Journal article
Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk
Abstract
BACKGROUND AND AIMS: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDRs) of CD patients is an independent risk factor for future CD development.
METHODS: We measured host serum antibody response to 6 microbial antigens at enrollment (Prometheus enzyme-linked …
Authors
Lee S-H; Turpin W; Espin-Garcia O; Garay JAR; Smith MI; Leibovitzh H; Goethel A; Turner D; Mack D; Deslandres C
Journal
Gastroenterology, Vol. 161, No. 5, pp. 1540–1551
Publisher
Elsevier
Publication Date
November 2021
DOI
10.1053/j.gastro.2021.07.009
ISSN
0016-5085
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAntibodies, BacterialAntigens, BacterialAsymptomatic DiseasesBiomarkersC-Reactive ProteinCase-Control StudiesChildCrohn DiseaseFemaleGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansInflammation MediatorsIntestinal MucosaIsraelMaleMediation AnalysisNorth AmericaPermeabilityProspective StudiesRisk AssessmentRisk FactorsYoung Adult