Journal article
Interpreting Metabolomic Profiles using Unbiased Pathway Models
Abstract
Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the underlying biologic state of individuals through non-invasive interrogation of plasma metabolite levels. We analyzed metabolite profiles from an oral glucose tolerance test (OGTT) in 50 individuals, 25 with normal (NGT) and 25 with …
Authors
Deo RC; Hunter L; Lewis GD; Pare G; Vasan RS; Chasman D; Wang TJ; Gerszten RE; Roth FP
Journal
PLOS Computational Biology, Vol. 6, No. 2,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pcbi.1000692
ISSN
1553-734X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid Transport SystemsCarrier ProteinsCluster AnalysisComputational BiologyExtracellular SpaceGABA Plasma Membrane Transport ProteinsGlucoseGlucose Metabolism DisordersGlucose Tolerance TestHumansIntracellular SpaceMetabolic Networks and PathwaysMetabolomeModels, BiologicalPrincipal Component Analysis