Journal article
IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Abstract
RATIONALE: Nontypeable Haemophilus influenzae (NTHi) causes acute exacerbation of chronic obstructive pulmonary disease (AECOPD). IL-17A is central for neutrophilic inflammation and has been linked to COPD pathogenesis.
OBJECTIVES: We investigated whether IL-17A is elevated in NTHi-associated AECOPD and required for NTHi-exacerbated pulmonary neutrophilia induced by cigarette smoke.
Authors
Roos AB; Sethi S; Nikota J; Wrona CT; Dorrington MG; Sandén C; Bauer CMT; Shen P; Bowdish D; Stevenson CS
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 192, No. 4, pp. 428–437
Publisher
American Thoracic Society
Publication Date
August 15, 2015
DOI
10.1164/rccm.201409-1689oc
ISSN
1073-449X