Mechanisms of T Cell Peptide Epitope-Dependent Late Asthmatic Reactions Academic Article uri icon

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abstract

  • Short peptide sequences corresponding to T cell epitopes have been identified in the major cat allergen Fel d 1. In order to directly activate allergen-specific T cells in cat-allergic asthmatic individuals, peptides were administered by intradermal injection. Subsequently, a proportion of subjects experienced a delayed reduction of airway calibre manifested as a decrease in FEV(1). Changes in lung function occurred approximately 3 h after peptide injection, peaked at 6 h and resembled an isolated late asthmatic reaction (LAR). Using molecular tissue typing techniques, it was determined that many of the individuals experiencing isolated LAR expressed particular HLA-DR molecules. These molecules were shown in subsequent experiments to bind individual peptides within the preparation and thus to activate T cells in a major histocompatibility complex (MHC)-restricted fashion. The precise mechanisms whereby MHC-restricted activation of allergen-specific T cells gives rise to bronchoconstriction are currently under investigation.

authors

  • Larche, Mark
  • Haselden, Brigitte M
  • Oldfield, William LG
  • Shirley, Karen
  • North, Janet
  • Meng, Qiu
  • Robinson, Douglas S
  • Ying, Sun
  • Kay, A Barry

publication date

  • 2001