Mark Larche - McMaster Experts

Affiliations

McMaster University,
Faculty of Health Sciences, McMaster University
Member, McMaster Immunology Research Centre (MIRC), Faculty of Health Sciences
Professor Emeritus, Medicine, Faculty of Health Sciences
Canada Research Chair in Allergy and Immune Tolerance, McMaster University,
McMaster University/GSK Chair in Lung Immunology at St. Joseph's Healthcare, Medicine, Firestone Institute for Respiratory Health, The Research Institute at St. Joe's, McMaster University
Honorary Professorial Fellow, National Heart and Lung Institute, Imperial College London

Scholarly Activity in McMaster Experts

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selected scholarly activity

chapters
- Peptide-Based Therapeutic Vaccines for Allergic Diseases: Where Do We Stand?. 79-90. 2010
- Novel Approaches to Allergen Immunotherapy. 1555-1564. 2008
- Allergen-Specific Immunotherapy. Lung Biology in Health and Disease. 305-326. 2002
- Allergen, IgE and Mast-Cell-Directed Therapies: An Overview. Progress in Respiratory Research. 181-185. 2001
- Peptide Immunotherapy. Progress in Respiratory Research. 191-194. 2001
conferences
- Role of CD4+T Cells in the Pathogenesis of RA: Immunization with Citrullinated T Cell Epitopes Is Sufficient to Induce Immunological and Clinical Manifestations of Arthritis in DR4-Transgenic Mice. Arthritis & Rheumatology. 3159-3160. 2021
- Accumulation of Allergen-specific CD4+ T cells in the Airways after Segmental Allergen Challenge is Associated with Reduced Expression of T2 Chemoattractant Receptors on Allergen-specific CD4+ T cells in Blood. Journal of Allergy and Clinical Immunology. AB236-AB236. 2021
- Field Study of a Novel Synthetic Peptide Immunotherapy in Cat Allergic Patients. Journal of Allergy and Clinical Immunology. AB432-AB432. 2019
- PVX108 Peptide Immunotherapy Significantly Reduces Markers of Peanut-Induced Anaphylaxis in a Dose-Dependent Manner. Journal of Allergy and Clinical Immunology. AB426-AB426. 2019
- Identification And Validation Of Unique And Shared M2 Macrophage Biomarkers Between Murine Models And Human Disease Using Bioinformatic Gene Expression Analysis. American Journal of Respiratory and Critical Care Medicine. 2017
- The Hsp90 Inhibitor Radicicol As A Bioinformatically-Derived Drug For M2 Macrophage Phenotype Inhibition. American Journal of Respiratory and Critical Care Medicine. 2017
- AllerGen’s 8th research conference. Allergy, Asthma and Clinical Immunology. 63. 2016
- Peptide immunotherapy in allergic disease: targeting T cells to induce tolerance. European Journal of Immunology. 753-754. 2016
- RNA-seq transcriptome analysis of human allergen-specific T cells suggests a role for IL-8 downregulation and modulation of allergic inflammatory cells as one of several potential mechanisms of action of intradermal immunotherapy with Fel d 1 synthetic peptides. Allergy. European Journal of Allergy and Clinical Immunology. 4-4. 2016
- Ara h 1 Peptide Immunotherapy Protects Against Peanut-Induced Anaphylaxis in a Dose-Dependent Manner. Journal of Allergy and Clinical Immunology. AB410-AB410. 2016
- Epicutaneous Allergen Exposure Dose Determines Manifestation of Allergic Airway Disease in Mice. Journal of Allergy and Clinical Immunology. AB395-AB395. 2016
- Fel d 1 Peptide Immunotherapy Ameliorates Both Cat and Ovalbumin Responses, in a Dual Allergen Murine Model of Allergic Airways Disease. Journal of Allergy and Clinical Immunology. AB64-AB64. 2016
- Comparison of the treatment effect of house dust mite synthetic peptide immuno-regulatory epitopes in the environmental exposure chamber and field setting two years after a short course of treatment. Allergy. European Journal of Allergy and Clinical Immunology. 28-28. 2015
- Persistent treatment effect with grass synthetic peptide immuno-regulatory epitopes (Grass-SPIRE) on grass allergy symptoms in the environmental exposure unit after a third season of natural exposure. Allergy. European Journal of Allergy and Clinical Immunology. 41-41. 2015
- Whole blood immune transcriptome profiling reveals systemic pathways associated with the mechanism of action of cat-synthetic peptide immunoregulatory epitopes. Allergy. European Journal of Allergy and Clinical Immunology. 632-632. 2015
- A Bell-Shaped Dose-Dependent Induction of Allergen-Specific Tetramer+ CD4 T Cells and Activated Lung ILC2s Following Epicutaneous Allergen Sensitization in HLA-DR4 Transgenic Mice. Journal of Allergy and Clinical Immunology. AB83-AB83. 2015
- Ara h 1 Peptide Immunotherapy Ameliorates Peanut-Induced Anaphylaxis. Journal of Allergy and Clinical Immunology. AB158-AB158. 2015
- Initial Evidence of Sustained Efficacy of House Dust Mite Synthetic Peptide Immuno Regulatory Epitopes 2 Years after a Short Course of Treatment in House Dust Mite (HDM) Allergic Subjects. Journal of Allergy and Clinical Immunology. AB142-AB142. 2015
- Persistent Treatment Effect with Grass Synthetic Peptide Immuno-Regulatory Epitopes in Grass Allergy Symptoms in an Environmental Exposure Unit Challenge after a Second Season of Natural Pollen Exposure. Journal of Allergy and Clinical Immunology. AB158-AB158. 2015
- The Contribution of Peptide-MHC Affinity to the Efficacy of Peptide Immunotherapy in a Murine Model of Allergic Airways Disease. Journal of Allergy and Clinical Immunology. AB243-AB243. 2015
- The Nasal Allergen Challenge Protocol of the Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): Validation in a Clinical Trial of Cat Synthetic Peptide Immunoregulatory Epitopes (Cat-SPIRE). Journal of Allergy and Clinical Immunology. AB142-AB142. 2015
- Peptide Immunotherapy Reduces The Frequency Of Mitogen-Induced Calcium Mobilization In Splenic T Cells Following Allergic Sensitization To Cat Allergen. American Journal of Respiratory and Critical Care Medicine. 2015
- A short course of synthetic peptide immuno-regulatory epitopes derived from grass allergens leads to a reduction in grass allergy symptoms. Allergy. European Journal of Allergy and Clinical Immunology. 32-32. 2014
- Four doses of Der p derived synthetic peptide immuno-regulatory epitopes over 3 months results in a persistent treatment effect at 1 year on symptoms of House Dust Mite allergy. Allergy. European Journal of Allergy and Clinical Immunology. 31-32. 2014
- Inhibition of Lymphocyte Activation in Response to HLA Derived Peptides in Renal Transplant Recipients.. Transplantation. 882-882. 2014
- Inhibition of Lymphocyte Activation in Response to HLA Derived Peptides in Renal Transplant Recipients.. American Journal of Transplantation. 882-882. 2014
- Airway Tissue, But Not Luminal, Eosinophilia Is Related To The Magnitude Of Airway Hyperresponsiveness In a Transgenic Murine Model Of Cat Allergy. Journal of Allergy and Clinical Immunology. AB60-AB60. 2014
- Ex-Vivo Allergen Stimulation In Whole Blood: A Novel Approach For Evaluating Mechanisms Of Action Of Synthetic Peptide Immuno-Regulatory Epitopes. Journal of Allergy and Clinical Immunology. AB223-AB223. 2014
- Persistent Treatment Effect Achieved At One Year After Four Doses Of Der p Derived Synthetic Peptide Immuno-Regulatory Epitopes In An Exposure Chamber Model Of House Dust Mite Allergy. Journal of Allergy and Clinical Immunology. AB289-AB289. 2014
- Treatment With Synthetic Peptide Immuno-Regulatory Epitopes Derived From Grass Allergens Leads To a Substantial Reduction In Grass Allergy Symptoms In The Environmental Exposure Unit. Journal of Allergy and Clinical Immunology. AB290-AB290. 2014
- Cat-PAD demonstrates sustained, consistent treatment effect on allergic rhinoconjunctivitis in individual catallergic patients 1 and 2 years after four intradermal injections. Allergy. European Journal of Allergy and Clinical Immunology. 70-70. 2013
- Total nasal symptom scores are reduced in an EEC model of cat allergy two years after administration of four doses of Cat-PAD. Allergy. European Journal of Allergy and Clinical Immunology. 647-648. 2013
- 1. Two Year Persistent Treatment Effect Achieved After 4 Doses of Cat-Peptide Antigen Desensitization (Cat-PAD) in an Environmental Exposure Chamber (EEC) Model of Cat Allergy. Journal of Allergy and Clinical Immunology. AB147-AB147. 2013
- Safety and Tolerability of Escalating Doses of House Dust Mite- Peptide Antigen Desensitization (HDM-PAD). Journal of Allergy and Clinical Immunology. AB37-AB37. 2013
- Safety and Tolerability of Fel d 1-Derived Peptide Antigen Desensitization in Subjects with Controlled Asthma. Journal of Allergy and Clinical Immunology. AB206-AB206. 2013
- Strategies to Query and Display Allergy-Derived Epitope Data From the Immune Epitope Database (IEDB). Journal of Allergy and Clinical Immunology. AB209-AB209. 2013
- Persistent Impairments in Humoral and Cellular Immunity in Patients with Immune Thrombocytopenia Treated with Rituximab: A Sub-Study of a Randomized Controlled Trial. Blood. 2012
- Persistent Impairments in Humoral and Cellular Immunity in Patients with Immune Thrombocytopenia Treated with Rituximab: A Sub-Study of a Randomized Controlled Trial. Blood. 492-492. 2012
- Persistent treatment effect on ocular and nasal symptoms of cat allergy 1 year after four doses of Fel d 1 peptide immunotherapy. Allergy. European Journal of Allergy and Clinical Immunology. 13-13. 2012
- Safety and efficacy of Fel d 1 derived peptide immunotherapy in a double-blind, placebo-controlled environmental exposure chamber study. Allergy. European Journal of Allergy and Clinical Immunology. 90-90. 2012
- Persistent Treatment Effect Achieved at One Year After 4 Doses of Fel d 1-Derived Peptide Immunotherapy in an Environmental Exposure Chamber (EEC) Model of Cat Allergy. Journal of Allergy and Clinical Immunology. AB144-AB144. 2012
- Suppression of Allergic Airway Inflammation by Low Dose, Intranasally Administered Der p 1 Derived Peptides, in a Murine Model of House Dust Mite Allergy. Journal of Allergy and Clinical Immunology. AB241-AB241. 2012
- A Comparison Of Four Flow Cytometric Gating Strategies In The Quantification Of Natural T Regulatory Cells In A Population Of Allergic Asthmatic Subjects. American Journal of Respiratory and Critical Care Medicine. 2011
- Development and Preliminary Clinical Evaluation of a Peptide Immunotherapy Vaccine for Cat Allergy. Journal of Allergy and Clinical Immunology. AB219-AB219. 2011
- Induction of Thymic Stromal Lymphopoietin (TSLP) in Airway Epithelium by Recombinant Allergens. Journal of Allergy and Clinical Immunology. AB125-AB125. 2011
- Successful Clinical Outcomes in Canadian Early Inflammatory Arthritis Patients: Data from the CATCH Study. Journal of Rheumatology. 2591-2591. 2009
- INDIRECT ALLORECOGNITION OF HLA 'PUBLIC' T-CELL EPITOPES IS ASSOCIATED WITH CHRONIC ALLOGRAFT DYSFUNCTION. Transplant International. 51-51. 2009
- ASSESSMENT OF FRACTURE RISK AND RECOMMENDATION FOR OSTEOPOROSIS TREATMENT IN WOMEN UNDERGOING THEIR FIRST DEXA SCAN: A COMPARISON BETWEEN BMD, BONE DESTINY AND OSTEOPOROSIS CANADA GUIDELINES. Osteoporosis International. S195-S195. 2009
- ASSESSMENT OF FRACTURE RISK AND TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN: A COMPARISON OF BMD, BONE DESTINY AND OC GUIDELINES. Osteoporosis International. S196-S196. 2009
- BONE DESTINY: A ONE-STEP GLOBAL FRACTURE RISK PREDICTOR FOR CLINICIANS. Osteoporosis International. S224-S225. 2009
- FRACTURE RISK ASSESSMENT AND TREATMENT RECOMMENDATIONS IN FEMALES WITH FRAGILITY FRACTURES ASSESSED BY BMD, BONE DESTINY AND OSTEOPOROSIS CANADA GUIDELINES. Osteoporosis International. S195-S196. 2009
- FRACTURE RISK ASSESSMENT AND TREATMENT RECOMMENDATIONS IN MALES WITH FRAGILITY FRACTURES ASSESSED BY BMD, BONE DESTINY AND OSTEOPOROSIS CANADA GUIDELINES. Osteoporosis International. S196-S197. 2009
- Immunological mechanism of peptide-based immunotherapy in a murine model of acute house dust mite exposure. Allergy. European Journal of Allergy and Clinical Immunology. 227-227. 2009
- BONE DESTINY - A One Step Fracture Risk Predictor for Clinicians.. Journal of Bone and Mineral Research. S372-S373. 2008
- Patients with Fragility Fracture Assessed by BNID, Bone DESTINY and Osteoporosis Canada Guidelines. Journal of Bone and Mineral Research. S198-S198. 2008
- Airway Expression of Calcitonin Gene-Related Peptide in T-Cell Peptide-Induced Late Asthmatic Reactions. Journal of Allergy and Clinical Immunology. S188-S188. 2006
- Peptide Immunotherapy in Fel d 1-Sensitized HLA-DR1 Transgenic Mice is Associated with Increased IL-10 but Independent of TGFbeta and Foxp3 Expression. Journal of Allergy and Clinical Immunology. S327-S327. 2006
- Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Efficacy of Immunotherapy. Journal of Allergy and Clinical Immunology. S330-S330. 2006
- Peptide therapy in allergic disease. Immunology. 44-44. 2005
- Analytical validation of a novel flow cytometric-based Facilitated Allergen Presentation (FAP) assay as a tool for monitoring allergen-specific immunotherapy. Clinical and Experimental Allergy. 1415-1415. 2005
- Allergen-derived T cell peptides in immunotherapy. Revue Francaise d'Allergologie et d'Immunologie Clinique. 59-63. 2003
- Induction of antigen-specific T-cell regulation through peptide immunotherapy. ALLERGY FRONTIERS AND FUTURES. 320-323. 2003
- Desensitization (“Tolerance”) induced by allergen-derived T cell peptide epitopes: Evidence for the induction of linked suppression. Journal of Allergy and Clinical Immunology. S261-S261. 2002
- Inhalation of allergen-derived T cell peptide epitopes induces isolated late asthmatic reactions with associated local eosinophilia. Journal of Allergy and Clinical Immunology. S167-S167. 2002
- T cell peptide epitope immunotherapy is accompanied by local increases in CD25+T cells. Journal of Allergy and Clinical Immunology. S362-S362. 2002
- A dosing protocol of allergen-derived T cell peptide epitopes for the treatment of allergic disease. Journal of Allergy and Clinical Immunology. S217-S217. 2001
- A double-blind, placebo-controlled study of short peptides derived from Fel d1 in cat-allergic subjects. Journal of Allergy and Clinical Immunology. S216-S216. 2001
- Attenuation of cutaneous and bronchial late allergic reactions by short allergen-derived peptides is associated with a reduction in peptide and whole allergen-induced T cell effector function. Journal of Allergy and Clinical Immunology. S67-S67. 2001
- 111 Attenuation of late cutaneous and asthmatic reactions following administration of short allergen-derived T cell peptide epitopes. Journal of Allergy and Clinical Immunology. S380-S380. 2000
- 468 Induction of cutaneous and bronchial hyporesponsiveness by short allergen-derived peptides. Journal of Allergy and Clinical Immunology. S154-S154. 2000
- 752 Blood eosinophils from atopic donors express messenger RNA for the ?, ?, ?*, and ?* subunits of the high affinity IgE receptor (Fc?RI) and intracellular, but not cell surface, ? subunit protein. Journal of Allergy and Clinical Immunology. S253-S253. 2000
- 753 Some pitfalls in measuring human eosinophil numbers in blood and tissues. Journal of Allergy and Clinical Immunology. S253-S253. 2000
- 825 Mechanisms of the late asthmatic reaction induced by IgE-independent MHC-restricted T cell peptide epitopes. Journal of Allergy and Clinical Immunology. S281-S281. 2000
- Intramolecular variation in cytokine production profiles in allergic asthma: A comparison of allergen peptide-specific responses in defined clinical groups.. Journal of Allergy and Clinical Immunology. S230-S230. 1999
- Peptide-induced late asthmatic reactions following MHC-restricted T cell activation in vitro.. Journal of Allergy and Clinical Immunology. S204-S204. 1999
- Asthma provoked by T-cell peptide epitopes. Journal of Allergy and Clinical Immunology. S146-S146. 1998
- In vitro up-regulation of Fc epsilon RI on human peripheral blood eosinophils from atopic subjects.. Journal of Allergy and Clinical Immunology. S96-S96. 1998
- Mapping of T cell epitopes of chain 1 Fel d 1 by primary peripheral blood mononuclear cell proliferation assays in cat allergic asthmatics, cat allergic rhinitics, non cat allergic asthmatics and normal controls.. Journal of Allergy and Clinical Immunology. S142-S143. 1998
- Bronchoalveolar lavage macrophages from atopic asthmatics, but not normal subjects, display CD86-dependent antigen presenting cell function, although CD86 is equally expressed by asthmatic and control macrophages.. Journal of Allergy and Clinical Immunology. 493-493. 1997
- Dependence of allergen-induced T cell proliferation and cytokine production on CD28/B7 co-stimulation.. Journal of Allergy and Clinical Immunology. 1650-1650. 1997
- Expression of IL-4 and IL-5 mRNA and protein product by CD4(+) and CD8(+) T cells, eosinophils (Eos) and mast cells in bronchial mucosa of atopic (AA) and non-atopic (NAA) asthmatics.. Journal of Allergy and Clinical Immunology. 508-508. 1997
- IL-5 secretion by allergen-specific CD4+ cells in shortterm culture: Dissociation from allergen-induced proliferation and dependence on B7-2 co-stimulation.. Journal of Allergy and Clinical Immunology. 708-708. 1996
- T-CELL RECEPTOR (TCR) GENE REARRANGEMENT INVIVO AND INVITRO. Journal of Immunology. A31-A31. 1993
- ANALYSIS OF THE HUMAN ANTI-MOUSE IG RESPONSE IN PATIENTS RECEIVING MURINE MONOCLONAL-ANTIBODIES. British Journal of Cancer. 540-540. 1986
- HUMAN ANTI-MOUSE IMMUNOGLOBULIN RESPONSES IN PATIENTS RECEIVING MONOCLONAL-ANTIBODIES. British Journal of Cancer. 659-659. 1985
- CONCERNING A RARE TRAUMATIC INJURY - FRACTURE OF A SESAMOID OF BIG TOE IN AN ACCIDENT ON WAY TO WORK. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. 807-808. 1976
- DEADLY ACCIDENT WITH A STUD DRIVER - MEDICAL AND TECHNOLOGICAL STUDY. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. 571-573. 1976
- WOUND OF RIGHT INDEX BY A LIQUID UNDER PRESSURE, HAVING NEEDED A GRAFT OF SOFT PARTS. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. 801-802. 1976
journal articles
- Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy. Acta Allergologica. 79:485-498. 2024
- Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management. Research and Practice in Thrombosis and Haemostasis. 7:100097-100097. 2023
- One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence. Acta Allergologica. 77:454-468. 2022
- T cell–mediated autoimmunity in immune thrombocytopenia. European Journal of Haematology. 108:18-27. 2022
- Technical standards in allergen exposure chambers worldwide – an EAACI Task Force Report. Acta Allergologica. 76:3589-3612. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA. Acta Allergologica. 76:2177-2188. 2021
- Immunological changes in peripheral blood following nasal allergen challenge in subjects with allergic rhinitis pre‐ and post‐peptide immunotherapy: An open‐label clinical study. Acta Allergologica. 76:1907-1911. 2021
- Obituary: Anthony Barrington Kay (1939‐2020). Acta Allergologica. 76:969-969. 2021
- Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen. Journal of Allergy and Clinical Immunology. 145:1585-1597. 2020
- Increased cytotoxic potential of CD8⁺T cells in immune thrombocytopenia. British Journal of Haematology. 188:e72-e76. 2020
- Modulation of CRTh2 expression on allergen‐specific T cells following peptide immunotherapy. Acta Allergologica. 74:2157-2166. 2019
- Value of 111In-Pentetreotide scintigraphy and 18F-FDG PET for clinical prognosis of patients with neuroendocrine neoplasms. Nuklearmedizin - NuclearMedicine. 43:316-322. 2019
- Legends of allergy/immunology: A. Barry Kay. Acta Allergologica. 74:1588-1590. 2019
- Induction of bystander tolerance and immune deviation after Fel d 1 peptide immunotherapy. Journal of Allergy and Clinical Immunology. 143:1087-1099.e4. 2019
- The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC): verification of nasal allergen challenge procedures in a study utilizing an investigational immunotherapy for cat allergy. Clinical and Translational Allergy. 8:15. 2018
- Cellular immune responses to platelet factor 4 and heparin complexes in patients with heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 16:1402-1412. 2018
- Perspectives in allergen immunotherapy: 2017 and beyond. Acta Allergologica. 73:5-23. 2018
- Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015. Allergy, Asthma and Clinical Immunology. 13:10. 2017
- Investigating Immune Gene Signatures in Peripheral Blood from Subjects with Allergic Rhinitis Undergoing Nasal Allergen Challenge. Journal of Immunology. 199:3395-3405. 2017
- Treatment with grass allergen peptides improves symptoms of grass pollen–induced allergic rhinoconjunctivitis. Journal of Allergy and Clinical Immunology. 140:486-496. 2017
- Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future – an EAACI Position Paper. Acta Allergologica. 72:1035-1042. 2017
- Novel approaches and perspectives in allergen immunotherapy. Acta Allergologica. 72:1022-1034. 2017
- An Update on Lymphocyte Subtypes in Asthma and Airway Disease. Chest. 151:1122-1130. 2017
- Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016. Allergy, Asthma and Clinical Immunology. 13. 2017
- Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016. Allergy, Asthma and Clinical Immunology. 13. 2017
- Erratum to: Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement. World Allergy Organization Journal. 10:6-6. 2017
- In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?. PLoS ONE. 12:e0177813-e0177813. 2017
- Concepts and perspectives on peptide-based immunotherapy in allergy. Allergo Journal International. 25:144-153. 2016
- Concepts and perspectives on peptide-based immunotherapy in allergy. Allergo Journal. 25:22-31. 2016
- Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index. JAMA Pediatrics. 170:662-662. 2016
- Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015. Allergy, Asthma and Clinical Immunology. 12:22. 2016
- Treatment with anti‐cytokine monoclonal antibodies can potentiate the target cytokine rather than neutralize its activity. Acta Allergologica. 71:283-285. 2016
- Infant gut immunity: a preliminary study of IgA associations with breastfeeding. Journal of Developmental Origins of Health and Disease. 7:68-72. 2016
- Concepts and perspectives on peptide-based immunotherapy in allergy. Allergo Journal International. 25:144-153. 2016
- Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015. Allergy, Asthma and Clinical Immunology. 12. 2016
- Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement. World Allergy Organization Journal. 9:33-33. 2016
- TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS Pathogens. 12:e1005368-e1005368. 2016
- T regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non‐asthmatic and asthmatic subjects. Clinical and Experimental Allergy. 45:1654-1662. 2015
- Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy. Acta Allergologica. 70:495-505. 2015
- Fel d 1‐derived synthetic peptide immuno‐regulatory epitopes show a long‐term treatment effect in cat allergic subjects. Clinical and Experimental Allergy. 45:974-981. 2015
- Infant gut microbiota and food sensitization: associations in the first year of life. Clinical and Experimental Allergy. 45:632-643. 2015
- Peptide Immunotherapy; Short but Long Lasting?. Current Treatment Options in Allergy. 2:64-71. 2015
- Allergen immunotherapy on the way to product-based evaluation—a WAO statement. World Allergy Organization Journal. 8:29-29. 2015
- Mechanisms of Peptide Immunotherapy in Allergic Airways Disease. Annals of the American Thoracic Society. 11:S292-S296. 2014
- T cell‐mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells. Clinical and Experimental Allergy. 44:953-964. 2014
- Associations between bacterial communities of house dust and infant gut. Environmental Research. 131:25-30. 2014
- Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35. Mucosal Immunology. 7:379-390. 2014
- Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma. Journal of Allergy and Clinical Immunology. 133:696-703. 2014
- OX40L blockade and allergen‐induced airway responses in subjects with mild asthma. Clinical and Experimental Allergy. 44:29-37. 2014
- Eosinophil-basophil progenitors and atopic risk. Allergo Journal. 22:553-555. 2013
- Cytokine responses of peripheral blood mononuclear cells to allergen do not identify asthma or asthma phenotypes. Clinical and Experimental Allergy. 43:1226-1235. 2013
- The effect of rituximab on vaccine responses in patients with immune thrombocytopenia. Blood. 122:1946-1953. 2013
- Two year persistent treatment effect in reducing nasal symptoms of cat allergy after 4 doses of Cat‐PAD, the first in a new class of synthetic peptide immuno‐regulatory epitopes. Clinical and Translational Allergy. 3:o7-o7. 2013
- New Directions in Immunotherapy. Current Allergy and Asthma Reports. 13:178-195. 2013
- Fel d 1–derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: A randomized, placebo-controlled study. Journal of Allergy and Clinical Immunology. 131:103-109.e7. 2013
- Immunotherapy – 2067. FEL d 1 peptide antigen desensitization safety and efficacy in a double-blind, placebo-controlled environmental exposure chamber study. World Allergy Organization Journal. 6:P150-P150. 2013
- Immunotherapy – 2080. Fel d 1 derived peptide antigen desensitization results in a persistent treatment effect on symptoms of cat allergy 1 year after 4 doses. World Allergy Organization Journal. 6:P162-P162. 2013
- Mechanisims of asthma and allergic disease – 1085. Safety and tolerability of escalating doses of house dust mite peptide antigen desensitisation. World Allergy Organization Journal. 6:P81-P81. 2013
- Strategies to Query and Display Allergy-Derived Epitope Data from the Immune Epitope Database. International Archives of Allergy and Immunology. 160:334-345. 2013
- Two year persistent treatment effect in reducing nasal symptoms of cat allergy after 4 doses of Cat-PAD, the first in a new class of synthetic peptide immuno-regulatory epitopes. Clinical and Translational Allergy. 3:O7-O7. 2013
- Functional rather than immunoreactive levels of IgG₄ correlate closely with clinical response to grass pollen immunotherapy. Acta Allergologica. 67:217-226. 2012
- Validation of Peptide Immunotherapy as a New Approach in the Treatment of Allergic Rhinoconjunctivitis: The Clinical Benefits of Treatment with Amb a 1 Derived T cell Epitopes. Journal of Allergy and Clinical Immunology. 129:AB368-AB368. 2012
- Immunotherapy with peptides. Acta Allergologica. 66:784-791. 2011
- Peptide and Recombinant Immunotherapy. Immunology and Allergy Clinics of North America. 31:377-389. 2011
- T Lymphocyte Responses to Nonpolymorphic HLA-Derived Peptides Are Associated With Chronic Renal Allograft Dysfunction. Transplantation. 91:279-286. 2011
- Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. Journal of Allergy and Clinical Immunology. 127:89-97.e14. 2011
- T Cell Epitope-Based Allergy Vaccines. Current Topics in Microbiology and Immunology. 352:107-119. 2011
- Chronic Graft Versus Host Disease Is Associated With an Immune Response to Autologous Human Leukocyte Antigen–Derived Peptides. Transplantation. 90:555-563. 2010
- Immune mechanisms of sublingual immunotherapy: Are oral Langerhans cells the masters of tolerance?. Journal of Allergy and Clinical Immunology. 126:646-647. 2010
- Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression. Journal of Experimental Medicine (JEM). 206:1535-1547. 2009
- Serendipitous evidence of T lymphocyte activation in close female relatives of patients with systemic lupus erythematosus. Clinical and Experimental Immunology. 157:35-39. 2009
- Changing of the guard. Clinical and Experimental Allergy. 39:1-3. 2009
- Of cats and men: immunodominance and the role of HLA‐DP/DQ. Clinical and Experimental Allergy. 38:1709-1711. 2008
- Determining MHC Restriction of T-cell Responses. Methods in Molecular Medicine. 138:57-72. 2008
- Airway hyperresponsiveness and bronchial mucosal inflammation in T cell peptide-induced asthmatic reactions in atopic subjects. Thorax. 62:750-757. 2007
- Regulatory T Cells in Allergy and Asthma. Chest. 132:1007-1014. 2007
- Immunotherapy with Allergen Peptides. Allergy, Asthma and Clinical Immunology. 03:53-53. 2007
- Immunotherapy with Allergen Peptides. Allergy, Asthma and Clinical Immunology. 3:53-59. 2007
- Airway expression of calcitonin gene‐related peptide in T‐cell peptide‐induced late asthmatic reactions in atopics. Acta Allergologica. 62:495-503. 2007
- Indirect Recognition of T-Cell Epitopes Derived from the α3 and Transmembrane Domain of HLA-A2. American Journal of Transplantation. 7:1148-1157. 2007
- Update on the current status of peptide immunotherapy. Journal of Allergy and Clinical Immunology. 119:906-909. 2007
- Peptide immunotherapy for allergic diseases. Acta Allergologica. 62:325-331. 2007
- Immunoregulation by targeting T cells in the treatment of allergy and asthma. Current Opinion in Immunology. 18:745-750. 2006
- The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. Journal of Immunological Methods. 317:71-79. 2006
- Immunological mechanisms of allergen-specific immunotherapy. Nature Reviews Immunology. 6:761-771. 2006
- Immunotherapy with peptides.. Allergie et Immunologie. 38:240-243. 2006
- Peptide Immunotherapy. Immunology and Allergy Clinics of North America. 26:321-332. 2006
- Induction of interleukin‐10 and suppressor of cytokine signalling‐3 gene expression following peptide immunotherapy. Clinical and Experimental Allergy. 36:465-474. 2006
- Peptide therapy for allergic diseases: Basic mechanisms and new clinical approaches. Pharmacology and Therapeutics. 108:353-361. 2005
- Peptide-based immunotherapy: a novel strategy for allergic disease. Expert Review of Vaccines. 4:881-889. 2005
- Peptide-based vaccination: where do we stand?. Current Opinion in Allergy and Clinical Immunology. 5:537-543. 2005
- The effect of Fel d 1‐derived T‐cell peptides on upper and lower airway outcome measurements in cat‐allergic subjects. Acta Allergologica. 60:1269-1274. 2005
- Continuing Medical Education: an international reality. Acta Allergologica. 60:739-742. 2005
- Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nature Medicine. 11:S69-S76. 2005
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preprints
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