Immunological mechanisms of allergen-specific immunotherapy

Key PointsAllergen-specific immunotherapy (SIT) for allergic diseases is the oldest form of antigen-specific disease-modifying therapy.Administration of allergen by injection or mucosal (sublingual) application leads to amelioration of clinical symptoms and has lasting effects that exceed the period of treatment.Immunological changes that are associated with SIT include the induction of allergen-specific antibodies (mainly IgG but also IgA) …