Journal article
IgA potentiates NETosis in response to viral infection
Abstract
IgA is the second most abundant antibody present in circulation and is enriched at mucosal surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens including viruses. In addition to neutralizing viruses directly, IgA can also stimulate Fc-dependent effector functions via engagement of Fc alpha receptors (Fc-αRI) expressed on the surface of certain immune effector cells. Neutrophils are the most abundant …
Authors
Stacey HD; Golubeva D; Posca A; Ang JC; Novakowski KE; Zahoor MA; Kaushic C; Cairns E; Bowdish DME; Mullarkey CE
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 27,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
July 6, 2021
DOI
10.1073/pnas.2101497118
ISSN
0027-8424