Journal article
Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects
Abstract
PURPOSE OF REVIEW: Hematopoietic homeostasis depends on appropriate self-renewal and differentiation capacity of hematopoietic stem cells. The characterization of the key extracellular signals that integrate with intracellular molecular machinery to regulate hematopoietic stem cells fate choice is crucial to move toward hematopoietic stem cell clinical application.
RECENT FINDINGS: Several factors have been described as positive and negative …
Authors
Campbell C; Risueno RM; Salati S; Guezguez B; Bhatia M
Journal
Current Opinion in Hematology, Vol. 15, No. 4, pp. 319–325
Publisher
Wolters Kluwer
Publication Date
July 2008
DOI
10.1097/moh.0b013e328303b9df
ISSN
1065-6251