Recommendations for the clinical and laboratory diagnosis of VITT against COVID‐19: Communication from the ISTH SSC Subcommittee on Platelet Immunology Journal Articles uri icon

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  • Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.


  • Nazy, Ishac
  • Sachs, Ulrich J
  • Arnold, Donald
  • McKenzie, Steven E
  • Choi, Phil
  • Althaus, Karina
  • Ahlen, Maria Therese
  • Sharma, Ruchika
  • Grace, Rachael F
  • Bakchoul, Tamam

publication date

  • June 2021