Accuracy of Screening Tests for Celiac Disease in Asymptomatic Patients With Type 1 Diabetes Journal Articles uri icon

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abstract

  • INTRODUCTION: To evaluate the diagnostic performance of celiac serologic tests in asymptomatic patients with type 1 diabetes (T1D). METHODS: Patients with T1D asymptomatic for celiac disease were prospectively screened with immunoglobulin A anti-tissue transglutaminase. Test characteristics were calculated and optimal cutoffs for a positive screen determined. RESULTS: Two thousand three hundred fifty-three patients were screened and 101 proceeded to biopsy. The positive predictive value of immunoglobulin A anti-tissue transglutaminase at the assay referenced upper limit of normal (30CU) was 85.9%, and the sensitivity and specificity were 100% and 38%, respectively. DISCUSSION: Thresholds extrapolated from the general population for the diagnostic evaluation of celiac disease are not suitable for use in asymptomatic T1D patients. Population-specific screening cutoffs are required.

authors

  • Gould, Michelle J
  • Mahmud, Farid H
  • Clarke, Antoine BM
  • McDonald, Charlotte
  • Saibil, Fred
  • Punthakee, Zubin
  • Marcon, Margaret A

publication date

  • July 2021

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