Conference
Abstract 5780: Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)
Abstract
Abstract
The cellular response to DNA double-strand break (DSB) formation is an essential component of normal cell survival, following exposure to DNA-damaging chemicals and ionising radiation. The serine/threonine kinase DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol (PI) 3-kinase related kinase (PIKK) family of enzymes, and plays an important role in DNA DSB repair via the non-homologous …
Authors
Cano C; Bailey C; Bardos J; Curtin N; Frigerio M; Golding B; Hardcastle I; Hummersone M; Menear K; Newell D
Volume
70
Pagination
pp. 5780-5780
Publisher
American Association for Cancer Research (AACR)
Publication Date
April 15, 2010
DOI
10.1158/1538-7445.am10-5780
Conference proceedings
Cancer Research
Issue
8_Supplement
ISSN
0008-5472