Journal article
RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
Abstract
Pro-inflammatory M1 macrophage polarization is associated with microbicidal and antitumor responses. We recently described APOBEC3A-mediated cytosine-to-uracil (C > U) RNA editing during M1 polarization. However, the functional significance of this editing is unknown. Here we find that APOBEC3A-mediated cellular RNA editing can also be induced by influenza or Maraba virus infections in normal human macrophages, and by interferons in …
Authors
Alqassim EY; Sharma S; Khan ANMNH; Emmons TR; Cortes Gomez E; Alahmari A; Singel KL; Mark J; Davidson BA; Robert McGray AJ
Journal
Communications Biology, Vol. 4, No. 1,
Publisher
Springer Nature
DOI
10.1038/s42003-020-01620-x
ISSN
2399-3642