Journal article
Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection
Abstract
To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10(-5); odds ratio [OR], 0.68 …
Authors
Loeb M; Eskandarian S; Rupp M; Fishman N; Gasink L; Patterson J; Bramson J; Hudson TJ; Lemire M
Journal
The Journal of Infectious Diseases, Vol. 204, No. 7, pp. 1031–1037
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 2011
DOI
10.1093/infdis/jir493
ISSN
0022-1899
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
2',5'-Oligoadenylate SynthetaseAdultAgedAllelesCD13 AntigensCase-Control StudiesEncephalitis, ViralExonsFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMeningitis, ViralMiddle AgedMultigene FamilyNAV1.1 Voltage-Gated Sodium ChannelNerve Tissue ProteinsParalysisPolymorphism, Single NucleotidePromoter Regions, GeneticReceptors, CCR5Replication Protein CSodium ChannelsWest Nile Fever