Journal article
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
Abstract
BACKGROUND: Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.
METHODS: We performed a prospective trial involving women with …
Authors
Sparano JA; Gray RJ; Makower DF; Pritchard KI; Albain KS; Hayes DF; Geyer CE; Dees EC; Perez EA; Olson JA
Journal
The New England Journal of Medicine, Vol. 373, No. 21, pp. 2005–2014
Publisher
Massachusetts Medical Society
Publication Date
November 19, 2015
DOI
10.1056/nejmoa1510764
ISSN
0028-4793
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAge FactorsAgedAntineoplastic Agents, HormonalAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsChemotherapy, AdjuvantFemaleGene ExpressionGene Expression ProfilingHumansKaplan-Meier EstimateMastectomyMiddle AgedMultivariate AnalysisNeoplasm GradingNeoplasm Recurrence, LocalProspective StudiesReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneReverse Transcriptase Polymerase Chain ReactionSurvival Analysis