Differential photoelectrochemical DNA sensing by modulating the plasmonic properties of metal nanoparticles

Photoelectrochemical transduction methods are becoming a popular method to achieve the point-of-care device to detect various biomolecules. Herein, we present a differential assay to detect Au nanoparticle labeled-DNA strand with femtomolar sensitivity. To achieve the differential signaling, spatially separated multiplex electrodes were prepared by utilizing probe DNA as nano-spacers. The motional dynamics of the AuNP after hybridization …