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Antibody and Cell-Mediated Immune Responses Are...
Journal article

Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults

Abstract

Despite efforts to design better vaccines for older adults, the risk for serious complications of influenza remains disproportionately high. Identifying correlates of vaccine effectiveness and understanding the heterogeneity of health outcomes in older adults are key to the vaccine development pipeline. We sought correlates of protection against laboratory-confirmed influenza illness (LCII) in a 4-year randomized trial of standard versus …

Authors

Verschoor CP; Andrew MK; Loeb M; Pawelec G; Haynes L; Kuchel GA; McElhaney JE

Journal

Vaccines, Vol. 9, No. 1,

Publisher

MDPI

DOI

10.3390/vaccines9010025

ISSN

2076-393X