Journal article
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS
Abstract
Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation of available findings. GCs are agonist compounds that bind to the GC receptor (GR) producing a pharmacological response. Clinical efficacy depends on the magnitude and duration of exposure to GR. We updated the …
Authors
Meduri GU; Annane D; Confalonieri M; Chrousos GP; Rochwerg B; Busby A; Ruaro B; Meibohm B
Journal
Intensive Care Medicine, Vol. 46, No. 12, pp. 2284–2296
Publisher
Springer Nature
Publication Date
December 2020
DOI
10.1007/s00134-020-06289-8
ISSN
0342-4642