Journal article
Resequencing Genomic DNA of Patients With Severe Hypertriglyceridemia (MIM 144650)
Abstract
OBJECTIVE: The genetic determinants of severe hypertriglyceridemia (HTG; MIM 144650) in adults are poorly defined. We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for accumulation of missense mutations in patients with severe HTG compared with normolipidemic subjects.
METHODS AND RESULTS: We resequenced >2 million base pairs of genomic DNA from 110 nondiabetic patients with severe HTG and determined the …
Authors
Wang J; Cao H; Ban MR; Kennedy BA; Zhu S; Anand S; Yusuf S; Pollex RL; Hegele RA
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 27, No. 11, pp. 2450–2455
Publisher
Wolters Kluwer
Publication Date
November 2007
DOI
10.1161/atvbaha.107.150680
ISSN
1079-5642