Thinking small: Zinc sensing by the gut epithelium
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Intestinal sensing is critical to maintain homeostasis. The gut epithelium is predominantly inhabited by enterocytes that, in addition to their barrier and absorptive function, may play a surveillance role during nutrient uptake. Even insects such as Drosophila melanogaster possess a sophisticated nutrient-sensing system. This suggests that enterocytes translate nutrient cues into signals that regulate the local intestinal epithelium and likely impact the entire organism (growth and development, immunity, etc.).
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