Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation Conference Paper uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend <.001). In a subgroup of 2812 patients without pre-existing CHF at baseline, the corresponding aHRs were 1.0, 0.90 (0.47-1.72), 1.69 (0.94-3.04), and 3.48 (1.94-6.24) (P for trend <.001). Patients with IGFBP-7 and NT-proBNP levels above the biomarker-specific median had a higher risk of incident CHF hospitalization (aHR 5.20; 3.35-8.09) compared to those with only 1 elevated marker (elevated IGFBP-7 aHR 2.17; 1.30-3.60); elevated NT-proBNP aHR 1.97; 1.17-3.33); or no elevated marker (reference). CONCLUSION: Higher plasma levels of IGFBP-7 were strongly and independently associated with CHF hospitalization in AF patients. The prognostic information provided by IGFBP-7 was additive to that of NT-proBNP.

authors

  • Blum, Steffen
  • Aeschbacher, Stefanie
  • Meyre, Pascal
  • Kühne, Michael
  • Rodondi, Nicolas
  • Beer, Jürg H
  • Ammann, Peter
  • Moschovitis, Giorgio
  • Bonati, Leo H
  • Blum, Manuel R
  • Kastner, Peter
  • Baguley, Fiona
  • Sticherling, Christian
  • Osswald, Stefan
  • Conen, David
  • Aeschbacher, Stefanie
  • Auberson, Chloé
  • Blum, Steffen
  • Bonati, Leo
  • Ceylan, Selinda
  • Conen, David
  • Doerpfeld, Simone
  • Eken, Ceylan
  • Girod, Marc
  • Hämmerle, Peter
  • Krisai, Philipp
  • Kühne, Michael
  • Meyer-Zürn, Christine
  • Meyre, Pascal
  • Monsch, Andreas U
  • Müller, Christian
  • Osswald, Stefan
  • Springer, Anne
  • Sticherling, Christian
  • Szucs, Thomas
  • Voellmin, Gian
  • Zwimpfer, Leon
  • Osswald, Stefan
  • Kühne, Michael
  • Aujesky, Drahomir
  • Fischer, Urs
  • Fuhrer, Juerg
  • Roten, Laurent
  • Jung, Simon
  • Mattle, Heinrich
  • Adam, Luise
  • Aubert, Carole Elodie
  • Feller, Martin
  • Loewe, Axel
  • Moutzouri, Elisavet
  • Schneider, Claudio
  • Flückiger, Tanja
  • Groen, Cindy
  • Ehrsam, Lukas
  • Hellrigl, Sven
  • Nuoffer, Alexandra
  • Rakovic, Damiana
  • Schwab, Nathalie
  • Wenger, Rylana
  • Rodondi, Nicolas
  • Beynon, Christopher
  • Dillier, Roger
  • Deubelbeiss, Michèle
  • Eberli, Franz
  • Franzini, Christine
  • Juchli, Isabel
  • Liedtke, Claudia
  • Nadler, Jacqueline
  • Obst, Thayze
  • Roth, Jasmin
  • Schlomowitsch, Fiona
  • Schneider, Xiaoye
  • Studerus, Katrin
  • Tynan, Noreen
  • Weishaupt, Dominik
  • Müller, Andreas
  • Fontana, Simone
  • Kuest, Silke
  • Scheuch, Karin
  • Hischier, Denise
  • Bonetti, Nicole
  • Grau, Alexandra
  • Villinger, Jonas
  • Laube, Eva
  • Baumgartner, Philipp
  • Filipovic, Mark
  • Frick, Marcel
  • Montrasio, Giulia
  • Leuenberger, Stefanie
  • Rutz, Franziska
  • Beer, Jürg-Hans
  • Auricchio, Angelo
  • Anesini, Adriana
  • Camporini, Cristina
  • Conte, Giulio
  • Caputo, Maria Luce
  • Regoli, Francois
  • Moccetti, Tiziano
  • Brenner, Roman
  • Altmann, David
  • Gemperle, Michaela
  • Ammann, Peter
  • Firmann, Mathieu
  • Foucras, Sandrine
  • Rime, Martine
  • Hayoz, Daniel
  • Berte, Benjamin
  • Justi, Virgina
  • Kellner-Weldon, Frauke
  • Mehmann, Brigitta
  • Meier, Sonja
  • Roth, Myriam
  • Ruckli-Kaeppeli, Andrea
  • Russi, Ian
  • Schmidt, Kai
  • Young, Mabelle
  • Zbinden, Melanie
  • Kobza, Richard
  • Frangi-Kultalahti, Jane
  • Pin, Anica
  • Vicari, Luisa
  • Moschovitis, Giorgio
  • Ehret, Georg
  • Gallet, Hervé
  • Guillermet, Elise
  • Lazeyras, Francois
  • Lovblad, Karl-Olof
  • Perret, Patrick
  • Tavel, Philippe
  • Teres, Cheryl
  • Shah, Dipen
  • Lauriers, Nathalie
  • Méan, Marie
  • Salzmann, Sandrine
  • Schläpfer, Jürg
  • Grêt, Andrea
  • Novak, Jan
  • Vitelli, Sandra
  • Stephan, Frank-Peter
  • Frangi-Kultalahti, Jane
  • Gallino, Augusto
  • Di Valentino, Marcello
  • Witassek, Fabienne
  • Schwenkglenks, Matthias
  • Würfel, Jens
  • Altermatt, Anna
  • Amann, Michael
  • Huber, Petra
  • Ruberte, Esther
  • Sinnecker, Tim
  • Zuber, Vanessa
  • Coslovsky, Michael
  • Benkert, Pascal
  • Dutilh, Gilles
  • Markovic, Milica
  • Simon, Patrick
  • Schmid, Ramun

publication date

  • April 2021