Journal article
Clonidine in Patients Undergoing Noncardiac Surgery
Abstract
BACKGROUND: Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability.
METHODS: We performed a blinded, randomized trial with a 2-by-2 factorial design to allow separate evaluation of low-dose clonidine versus placebo and low-dose aspirin versus …
Authors
Devereaux PJ; Sessler DI; Leslie K; Kurz A; Mrkobrada M; Alonso-Coello P; Villar JC; Sigamani A; Biccard BM; Meyhoff CS
Journal
The New England Journal of Medicine, Vol. 370, No. 16, pp. 1504–1513
Publisher
Massachusetts Medical Society
Publication Date
April 17, 2014
DOI
10.1056/nejmoa1401106
ISSN
0028-4793