Journal article
Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation.
Abstract
Using a rat model of acute lung inflammation induced by intratracheal instillation of lipopolysaccharide (LPS), we investigated the kinetics of mRNA expression and the potential cellular sources of tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2), interleukin (IL)-1 beta, IL-6, RANTES, and transforming growth factor-beta 1 (TGF-beta 1). By Northern blot analysis, TNF-alpha and MIP-2 mRNAs in total lung tissue …
Authors
Xing Z; Jordana M; Kirpalani H; Driscoll KE; Schall TJ; Gauldie J
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 10, No. 2, pp. 148–153
Publisher
American Thoracic Society
Publication Date
February 1994
DOI
10.1165/ajrcmb.10.2.8110470
ISSN
1044-1549
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute DiseaseAnimalsBlotting, NorthernBronchoalveolar Lavage FluidChemokine CXCL2CytokinesDisease Models, AnimalInterleukin-1Interleukin-6KineticsLipopolysaccharidesMacrophagesMonokinesNeutrophilsPneumoniaRNA, MessengerRatsRats, Sprague-DawleyTransforming Growth Factor betaTumor Necrosis Factor-alpha