Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma.

Since inhibition of cyclo-oxygenase precipitates asthmatic attacks in patients with aspirin idiosyncrasy, we have evaluated the effects of pharmacological inhibition of the next enzyme in arachidonic acid cascade, i.e., thromboxane synthetase. Twelve patients with aspirin-induced asthma received on 3 days increasing doses (25-400 mg) of an imidazole derivative, OKY-046, which specifically blocks TXA2 synthetase. Twelve healthy controls received …