Journal article
Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis
Abstract
The transmembrane proteoglycan Syndecan contributes to cell surface signaling of diverse ligands in mammals, yet in Drosophila, genetic evidence links Syndecan only to the Slit receptor Roundabout and to the receptor tyrosine phosphatase LAR. Here we characterize the requirement for syndecan in the determination and morphogenesis of the Drosophila heart, and reveal two phases of activity, indicating that Syndecan is a co-factor in at least two …
Authors
Knox J; Moyer K; Yacoub N; Soldaat C; Komosa M; Vassilieva K; Wilk R; Hu J; de Lourdes Vazquez Paz L; Syed Q
Journal
Developmental Biology, Vol. 356, No. 2, pp. 279–290
Publisher
Elsevier
Publication Date
August 2011
DOI
10.1016/j.ydbio.2011.04.006
ISSN
0012-1606