Journal article
Global analyses of gene expression in early experimental osteoarthritis
Abstract
OBJECTIVE: To analyze genome-wide changes in chondrocyte gene expression in a surgically induced model of early osteoarthritis (OA) in rats, to assess the similarity of this model to human OA, and to identify genes and mechanisms leading to OA pathogenesis.
METHODS: OA was surgically induced in 5 rats by anterior cruciate ligament transection and partial medial meniscectomy. Sham surgery was performed in 5 additional animals, which were used as …
Authors
Appleton CTG; Pitelka V; Henry J; Beier F
Journal
Arthritis & Rheumatism, Vol. 56, No. 6, pp. 1854–1868
Publisher
Wiley
Publication Date
June 2007
DOI
10.1002/art.22711
ISSN
0004-3591
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ADAM ProteinsADAMTS5 ProteinAnimalsAnterior Cruciate LigamentArthritis, ExperimentalCartilage, ArticularChemokine CCL2Collagen Type IIDisease Models, AnimalGene Expression RegulationMaleMatrix Metalloproteinase 13Menisci, TibialOligonucleotide Array Sequence AnalysisOsteoarthritisProstaglandin-E SynthasesProstaglandin-Endoperoxide SynthasesRatsRats, Sprague-DawleyReceptors, CXCR4Reelin Protein